SPOP mutation induces DNA methylation via stabilizing GLP/G9a

The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prostate cancer cells susceptible to DNA demethylating a...

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Autores principales:	Jianong Zhang, Kun Gao, Hongyan Xie, Dejie Wang, Pingzhao Zhang, Ting Wei, Yuqian Yan, Yunqian Pan, Wenbin Ye, Huifen Chen, Qing Shi, Yao Li, Shi-min Zhao, Xiaonan Hou, Saravut J. Weroha, Yuzhuo Wang, Jun Zhang, R. Jeffrey Karnes, Housheng Hansen He, Liguo Wang, Chenji Wang, Haojie Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db75dbabc63044e4b2c4d83423549287
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:db75dbabc63044e4b2c4d834235492872021-12-02T19:16:47ZSPOP mutation induces DNA methylation via stabilizing GLP/G9a10.1038/s41467-021-25951-32041-1723https://doaj.org/article/db75dbabc63044e4b2c4d834235492872021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25951-3https://doaj.org/toc/2041-1723The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prostate cancer cells susceptible to DNA demethylating agents.Jianong ZhangKun GaoHongyan XieDejie WangPingzhao ZhangTing WeiYuqian YanYunqian PanWenbin YeHuifen ChenQing ShiYao LiShi-min ZhaoXiaonan HouSaravut J. WerohaYuzhuo WangJun ZhangR. Jeffrey KarnesHousheng Hansen HeLiguo WangChenji WangHaojie HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianong Zhang Kun Gao Hongyan Xie Dejie Wang Pingzhao Zhang Ting Wei Yuqian Yan Yunqian Pan Wenbin Ye Huifen Chen Qing Shi Yao Li Shi-min Zhao Xiaonan Hou Saravut J. Weroha Yuzhuo Wang Jun Zhang R. Jeffrey Karnes Housheng Hansen He Liguo Wang Chenji Wang Haojie Huang SPOP mutation induces DNA methylation via stabilizing GLP/G9a
description	The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prostate cancer cells susceptible to DNA demethylating agents.
format	article
author	Jianong Zhang Kun Gao Hongyan Xie Dejie Wang Pingzhao Zhang Ting Wei Yuqian Yan Yunqian Pan Wenbin Ye Huifen Chen Qing Shi Yao Li Shi-min Zhao Xiaonan Hou Saravut J. Weroha Yuzhuo Wang Jun Zhang R. Jeffrey Karnes Housheng Hansen He Liguo Wang Chenji Wang Haojie Huang
author_facet	Jianong Zhang Kun Gao Hongyan Xie Dejie Wang Pingzhao Zhang Ting Wei Yuqian Yan Yunqian Pan Wenbin Ye Huifen Chen Qing Shi Yao Li Shi-min Zhao Xiaonan Hou Saravut J. Weroha Yuzhuo Wang Jun Zhang R. Jeffrey Karnes Housheng Hansen He Liguo Wang Chenji Wang Haojie Huang
author_sort	Jianong Zhang
title	SPOP mutation induces DNA methylation via stabilizing GLP/G9a
title_short	SPOP mutation induces DNA methylation via stabilizing GLP/G9a
title_full	SPOP mutation induces DNA methylation via stabilizing GLP/G9a
title_fullStr	SPOP mutation induces DNA methylation via stabilizing GLP/G9a
title_full_unstemmed	SPOP mutation induces DNA methylation via stabilizing GLP/G9a
title_sort	spop mutation induces dna methylation via stabilizing glp/g9a
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db75dbabc63044e4b2c4d83423549287
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SPOP mutation induces DNA methylation via stabilizing GLP/G9a

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