Loss of immune tolerance to IL-2 in type 1 diabetes

Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.

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Autores principales:	Louis Pérol, John M. Lindner, Pamela Caudana, Nicolas Gonzalo Nunez, Audrey Baeyens, Andrea Valle, Christine Sedlik, Delphine Loirat, Olivier Boyer, Alain Créange, José Laurent Cohen, Ute Christine Rogner, Jun Yamanouchi, Martine Marchant, Xavier Charles Leber, Meike Scharenberg, Marie-Claude Gagnerault, Roberto Mallone, Manuela Battaglia, Pere Santamaria, Agnès Hartemann, Elisabetta Traggiai, Eliane Piaggio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db770a8739b84dbf870ffd96cace147e
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spelling	oai:doaj.org-article:db770a8739b84dbf870ffd96cace147e2021-12-02T14:38:33ZLoss of immune tolerance to IL-2 in type 1 diabetes10.1038/ncomms130272041-1723https://doaj.org/article/db770a8739b84dbf870ffd96cace147e2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13027https://doaj.org/toc/2041-1723Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.Louis PérolJohn M. LindnerPamela CaudanaNicolas Gonzalo NunezAudrey BaeyensAndrea ValleChristine SedlikDelphine LoiratOlivier BoyerAlain CréangeJosé Laurent CohenUte Christine RognerJun YamanouchiMartine MarchantXavier Charles LeberMeike ScharenbergMarie-Claude GagneraultRoberto MalloneManuela BattagliaPere SantamariaAgnès HartemannElisabetta TraggiaiEliane PiaggioNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Louis Pérol John M. Lindner Pamela Caudana Nicolas Gonzalo Nunez Audrey Baeyens Andrea Valle Christine Sedlik Delphine Loirat Olivier Boyer Alain Créange José Laurent Cohen Ute Christine Rogner Jun Yamanouchi Martine Marchant Xavier Charles Leber Meike Scharenberg Marie-Claude Gagnerault Roberto Mallone Manuela Battaglia Pere Santamaria Agnès Hartemann Elisabetta Traggiai Eliane Piaggio Loss of immune tolerance to IL-2 in type 1 diabetes
description	Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.
format	article
author	Louis Pérol John M. Lindner Pamela Caudana Nicolas Gonzalo Nunez Audrey Baeyens Andrea Valle Christine Sedlik Delphine Loirat Olivier Boyer Alain Créange José Laurent Cohen Ute Christine Rogner Jun Yamanouchi Martine Marchant Xavier Charles Leber Meike Scharenberg Marie-Claude Gagnerault Roberto Mallone Manuela Battaglia Pere Santamaria Agnès Hartemann Elisabetta Traggiai Eliane Piaggio
author_facet	Louis Pérol John M. Lindner Pamela Caudana Nicolas Gonzalo Nunez Audrey Baeyens Andrea Valle Christine Sedlik Delphine Loirat Olivier Boyer Alain Créange José Laurent Cohen Ute Christine Rogner Jun Yamanouchi Martine Marchant Xavier Charles Leber Meike Scharenberg Marie-Claude Gagnerault Roberto Mallone Manuela Battaglia Pere Santamaria Agnès Hartemann Elisabetta Traggiai Eliane Piaggio
author_sort	Louis Pérol
title	Loss of immune tolerance to IL-2 in type 1 diabetes
title_short	Loss of immune tolerance to IL-2 in type 1 diabetes
title_full	Loss of immune tolerance to IL-2 in type 1 diabetes
title_fullStr	Loss of immune tolerance to IL-2 in type 1 diabetes
title_full_unstemmed	Loss of immune tolerance to IL-2 in type 1 diabetes
title_sort	loss of immune tolerance to il-2 in type 1 diabetes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/db770a8739b84dbf870ffd96cace147e
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Loss of immune tolerance to IL-2 in type 1 diabetes

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