Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects

Oxygen is essential for cell survival and tissue regeneration. Scaffolds releasing oxygen have been hypothesized as an ideal strategy for bone repair. However, excessive oxygen supply will disturb the redox balance, lead to oxidative stress, and affect bone regeneration. In this study, we synthesize...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bin Zhao, Jingya He, Feng Wang, Ruxiao Xing, Bin Sun, Yanmin Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hydrogel oxygen supply vitamin C bone regeneration hypoxia Technology T
Acceso en línea:	https://doaj.org/article/db7930c61d08418496cdd48438675e53
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:db7930c61d08418496cdd48438675e53
record_format	dspace
spelling	oai:doaj.org-article:db7930c61d08418496cdd48438675e532021-11-17T05:06:07ZPolyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects2296-801610.3389/fmats.2021.758599https://doaj.org/article/db7930c61d08418496cdd48438675e532021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmats.2021.758599/fullhttps://doaj.org/toc/2296-8016Oxygen is essential for cell survival and tissue regeneration. Scaffolds releasing oxygen have been hypothesized as an ideal strategy for bone repair. However, excessive oxygen supply will disturb the redox balance, lead to oxidative stress, and affect bone regeneration. In this study, we synthesized a hydrogel from sodium alginate and loaded it calcium peroxide nanoparticles as an oxygen generating material and vitamin C as a pH regulator and antioxidant. The composite hydrogel, with a pH value close to physiological humoral fluid, could release oxygen to alleviate hypoxia in the bone defect and reduce the side effects of excessive hydrogen peroxide. In in vitro experiments, the composite hydrogel promoted the osteogenic differentiation and ALP and mineralization ability of rat bone marrow mesenchymal stem cells in a hypoxic environment (2% O2). In animal experiments, the composite hydrogel was applied in rat skull defect models. It promoted the healing of bone defects. These results suggest that sodium alginate hydrogel releasing oxygen and vitamin C is suitable for cell survival and tissue regeneration in a hypoxic environment and has good application prospects in bone defect repair.Bin ZhaoBin ZhaoJingya HeJingya HeFeng WangFeng WangRuxiao XingRuxiao XingBin SunBin SunYanmin ZhouYanmin ZhouFrontiers Media S.A.articlehydrogeloxygen supplyvitamin Cbone regenerationhypoxiaTechnologyTENFrontiers in Materials, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydrogel oxygen supply vitamin C bone regeneration hypoxia Technology T
spellingShingle	hydrogel oxygen supply vitamin C bone regeneration hypoxia Technology T Bin Zhao Bin Zhao Jingya He Jingya He Feng Wang Feng Wang Ruxiao Xing Ruxiao Xing Bin Sun Bin Sun Yanmin Zhou Yanmin Zhou Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects
description	Oxygen is essential for cell survival and tissue regeneration. Scaffolds releasing oxygen have been hypothesized as an ideal strategy for bone repair. However, excessive oxygen supply will disturb the redox balance, lead to oxidative stress, and affect bone regeneration. In this study, we synthesized a hydrogel from sodium alginate and loaded it calcium peroxide nanoparticles as an oxygen generating material and vitamin C as a pH regulator and antioxidant. The composite hydrogel, with a pH value close to physiological humoral fluid, could release oxygen to alleviate hypoxia in the bone defect and reduce the side effects of excessive hydrogen peroxide. In in vitro experiments, the composite hydrogel promoted the osteogenic differentiation and ALP and mineralization ability of rat bone marrow mesenchymal stem cells in a hypoxic environment (2% O2). In animal experiments, the composite hydrogel was applied in rat skull defect models. It promoted the healing of bone defects. These results suggest that sodium alginate hydrogel releasing oxygen and vitamin C is suitable for cell survival and tissue regeneration in a hypoxic environment and has good application prospects in bone defect repair.
format	article
author	Bin Zhao Bin Zhao Jingya He Jingya He Feng Wang Feng Wang Ruxiao Xing Ruxiao Xing Bin Sun Bin Sun Yanmin Zhou Yanmin Zhou
author_facet	Bin Zhao Bin Zhao Jingya He Jingya He Feng Wang Feng Wang Ruxiao Xing Ruxiao Xing Bin Sun Bin Sun Yanmin Zhou Yanmin Zhou
author_sort	Bin Zhao
title	Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects
title_short	Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects
title_full	Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects
title_fullStr	Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects
title_full_unstemmed	Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects
title_sort	polyacrylamide-sodium alginate hydrogel releasing oxygen and vitamin c promotes bone regeneration in rat skull defects
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/db7930c61d08418496cdd48438675e53
work_keys_str_mv	AT binzhao polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT binzhao polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT jingyahe polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT jingyahe polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT fengwang polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT fengwang polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT ruxiaoxing polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT ruxiaoxing polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT binsun polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT binsun polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT yanminzhou polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects AT yanminzhou polyacrylamidesodiumalginatehydrogelreleasingoxygenandvitamincpromotesboneregenerationinratskulldefects
_version_	1718425957281300480

Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects

Ejemplares similares