Non-invasively measured brain activity and radiological progression in diffuse glioma

Abstract Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance im...

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Autores principales:	T. Numan, S. D. Kulik, B. Moraal, J. C. Reijneveld, C. J. Stam, P. C. de Witt Hamer, J. Derks, A. M. E. Bruynzeel, M. E. van Linde, P. Wesseling, M. C. M. Kouwenhoven, M. Klein, T. Würdinger, F. Barkhof, J. J. G. Geurts, A. Hillebrand, L. Douw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db7a744192a044f1a2cdce3407df8c2d
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spelling	oai:doaj.org-article:db7a744192a044f1a2cdce3407df8c2d2021-12-02T18:13:52ZNon-invasively measured brain activity and radiological progression in diffuse glioma10.1038/s41598-021-97818-y2045-2322https://doaj.org/article/db7a744192a044f1a2cdce3407df8c2d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97818-yhttps://doaj.org/toc/2045-2322Abstract Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance imaging (MRI) in glioma patients. Postoperative magnetoencephalography (MEG) was recorded in 45 diffuse glioma patients. Brain activity was estimated using three measures (absolute broadband power, offset and slope) calculated at three spatial levels: global average, averaged across the peritumoral areas, and averaged across the homologues of these peritumoral areas in the contralateral hemisphere. Tumors were segmented on MRI. Changes in tumor volume between the two scans surrounding the MEG were calculated and correlated with brain activity. Brain activity was compared between patient groups classified into having increasing or stable tumor volume. Results show that brain activity was significantly increased in the tumor hemisphere in general, and in peritumoral regions specifically. However, none of the measures and spatial levels of brain activity correlated with changes in tumor volume, nor did they differ between patients with increasing versus stable tumor volumes. Longitudinal studies in more homogeneous subgroups of glioma patients are necessary to further explore the clinical potential of non-invasively measured brain activity.T. NumanS. D. KulikB. MoraalJ. C. ReijneveldC. J. StamP. C. de Witt HamerJ. DerksA. M. E. BruynzeelM. E. van LindeP. WesselingM. C. M. KouwenhovenM. KleinT. WürdingerF. BarkhofJ. J. G. GeurtsA. HillebrandL. DouwNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q T. Numan S. D. Kulik B. Moraal J. C. Reijneveld C. J. Stam P. C. de Witt Hamer J. Derks A. M. E. Bruynzeel M. E. van Linde P. Wesseling M. C. M. Kouwenhoven M. Klein T. Würdinger F. Barkhof J. J. G. Geurts A. Hillebrand L. Douw Non-invasively measured brain activity and radiological progression in diffuse glioma
description	Abstract Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance imaging (MRI) in glioma patients. Postoperative magnetoencephalography (MEG) was recorded in 45 diffuse glioma patients. Brain activity was estimated using three measures (absolute broadband power, offset and slope) calculated at three spatial levels: global average, averaged across the peritumoral areas, and averaged across the homologues of these peritumoral areas in the contralateral hemisphere. Tumors were segmented on MRI. Changes in tumor volume between the two scans surrounding the MEG were calculated and correlated with brain activity. Brain activity was compared between patient groups classified into having increasing or stable tumor volume. Results show that brain activity was significantly increased in the tumor hemisphere in general, and in peritumoral regions specifically. However, none of the measures and spatial levels of brain activity correlated with changes in tumor volume, nor did they differ between patients with increasing versus stable tumor volumes. Longitudinal studies in more homogeneous subgroups of glioma patients are necessary to further explore the clinical potential of non-invasively measured brain activity.
format	article
author	T. Numan S. D. Kulik B. Moraal J. C. Reijneveld C. J. Stam P. C. de Witt Hamer J. Derks A. M. E. Bruynzeel M. E. van Linde P. Wesseling M. C. M. Kouwenhoven M. Klein T. Würdinger F. Barkhof J. J. G. Geurts A. Hillebrand L. Douw
author_facet	T. Numan S. D. Kulik B. Moraal J. C. Reijneveld C. J. Stam P. C. de Witt Hamer J. Derks A. M. E. Bruynzeel M. E. van Linde P. Wesseling M. C. M. Kouwenhoven M. Klein T. Würdinger F. Barkhof J. J. G. Geurts A. Hillebrand L. Douw
author_sort	T. Numan
title	Non-invasively measured brain activity and radiological progression in diffuse glioma
title_short	Non-invasively measured brain activity and radiological progression in diffuse glioma
title_full	Non-invasively measured brain activity and radiological progression in diffuse glioma
title_fullStr	Non-invasively measured brain activity and radiological progression in diffuse glioma
title_full_unstemmed	Non-invasively measured brain activity and radiological progression in diffuse glioma
title_sort	non-invasively measured brain activity and radiological progression in diffuse glioma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db7a744192a044f1a2cdce3407df8c2d
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Non-invasively measured brain activity and radiological progression in diffuse glioma

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