Loss of egg yolk genes in mammals and the origin of lactation and placentation.

Embryonic development in nonmammalian vertebrates depends entirely on nutritional reserves that are predominantly derived from vitellogenin proteins and stored in egg yolk. Mammals have evolved new resources, such as lactation and placentation, to nourish their developing and early offspring. Howeve...

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Autores principales:	David Brawand, Walter Wahli, Henrik Kaessmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/db7f2bae746c4116a55fd6bcde0fda4c
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spelling	oai:doaj.org-article:db7f2bae746c4116a55fd6bcde0fda4c2021-11-25T05:33:26ZLoss of egg yolk genes in mammals and the origin of lactation and placentation.1544-91731545-788510.1371/journal.pbio.0060063https://doaj.org/article/db7f2bae746c4116a55fd6bcde0fda4c2008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18351802/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Embryonic development in nonmammalian vertebrates depends entirely on nutritional reserves that are predominantly derived from vitellogenin proteins and stored in egg yolk. Mammals have evolved new resources, such as lactation and placentation, to nourish their developing and early offspring. However, the evolutionary timing and molecular events associated with this major phenotypic transition are not known. By means of sensitive comparative genomics analyses and evolutionary simulations, we here show that the three ancestral vitellogenin-encoding genes were progressively lost during mammalian evolution (until around 30-70 million years ago, Mya) in all but the egg-laying monotremes, which have retained a functional vitellogenin gene. Our analyses also provide evidence that the major milk resource genes, caseins, which have similar functional properties as vitellogenins, appeared in the common mammalian ancestor approximately 200-310 Mya. Together, our data are compatible with the hypothesis that the emergence of lactation in the common mammalian ancestor and the development of placentation in eutherian and marsupial mammals allowed for the gradual loss of yolk-dependent nourishment during mammalian evolution.David BrawandWalter WahliHenrik KaessmannPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 3, p e63 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 David Brawand Walter Wahli Henrik Kaessmann Loss of egg yolk genes in mammals and the origin of lactation and placentation.
description	Embryonic development in nonmammalian vertebrates depends entirely on nutritional reserves that are predominantly derived from vitellogenin proteins and stored in egg yolk. Mammals have evolved new resources, such as lactation and placentation, to nourish their developing and early offspring. However, the evolutionary timing and molecular events associated with this major phenotypic transition are not known. By means of sensitive comparative genomics analyses and evolutionary simulations, we here show that the three ancestral vitellogenin-encoding genes were progressively lost during mammalian evolution (until around 30-70 million years ago, Mya) in all but the egg-laying monotremes, which have retained a functional vitellogenin gene. Our analyses also provide evidence that the major milk resource genes, caseins, which have similar functional properties as vitellogenins, appeared in the common mammalian ancestor approximately 200-310 Mya. Together, our data are compatible with the hypothesis that the emergence of lactation in the common mammalian ancestor and the development of placentation in eutherian and marsupial mammals allowed for the gradual loss of yolk-dependent nourishment during mammalian evolution.
format	article
author	David Brawand Walter Wahli Henrik Kaessmann
author_facet	David Brawand Walter Wahli Henrik Kaessmann
author_sort	David Brawand
title	Loss of egg yolk genes in mammals and the origin of lactation and placentation.
title_short	Loss of egg yolk genes in mammals and the origin of lactation and placentation.
title_full	Loss of egg yolk genes in mammals and the origin of lactation and placentation.
title_fullStr	Loss of egg yolk genes in mammals and the origin of lactation and placentation.
title_full_unstemmed	Loss of egg yolk genes in mammals and the origin of lactation and placentation.
title_sort	loss of egg yolk genes in mammals and the origin of lactation and placentation.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/db7f2bae746c4116a55fd6bcde0fda4c
work_keys_str_mv	AT davidbrawand lossofeggyolkgenesinmammalsandtheoriginoflactationandplacentation AT walterwahli lossofeggyolkgenesinmammalsandtheoriginoflactationandplacentation AT henrikkaessmann lossofeggyolkgenesinmammalsandtheoriginoflactationandplacentation
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Loss of egg yolk genes in mammals and the origin of lactation and placentation.

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