Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives

The aging of bone marrow (BM) remains a very imperative and alluring subject, with an ever-increasing interest among fellow scientists. A considerable amount of progress has been made in this field with the established ‘hallmarks of aging’ and continued efforts to investigate the age-related changes...

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Autores principales:	Payal Ganguly, Bradley Toghill, Shelly Pathak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aging bone marrow stem cells next-generation sequencing (NGS) genomics inflammaging Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/db7fce73b3ee440fb6110df6e2975092
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spelling	oai:doaj.org-article:db7fce73b3ee440fb6110df6e29750922021-11-25T17:54:29ZAging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives10.3390/ijms2222122251422-00671661-6596https://doaj.org/article/db7fce73b3ee440fb6110df6e29750922021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12225https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The aging of bone marrow (BM) remains a very imperative and alluring subject, with an ever-increasing interest among fellow scientists. A considerable amount of progress has been made in this field with the established ‘hallmarks of aging’ and continued efforts to investigate the age-related changes observed within the BM. Inflammaging is considered as a low-grade state of inflammation associated with aging, and whilst the possible mechanisms by which aging occurs are now largely understood, the processes leading to the underlying changes within aged BM remain elusive. The ability to identify these changes and detect such alterations at the genetic level are key to broadening the knowledgebase of aging BM. Next-generation sequencing (NGS) is an important molecular-level application presenting the ability to not only determine genomic base changes but provide transcriptional profiling (RNA-seq), as well as a high-throughput analysis of DNA–protein interactions (ChIP-seq). Utilising NGS to explore the genetic alterations occurring over the aging process within alterative cell types facilitates the comprehension of the molecular and cellular changes influencing the dynamics of aging BM. Thus, this review prospects the current landscape of BM aging and explores how NGS technology is currently being applied within this ever-expanding field of research.Payal GangulyBradley ToghillShelly PathakMDPI AGarticleagingbone marrowstem cellsnext-generation sequencing (NGS)genomicsinflammagingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12225, p 12225 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging bone marrow stem cells next-generation sequencing (NGS) genomics inflammaging Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	aging bone marrow stem cells next-generation sequencing (NGS) genomics inflammaging Biology (General) QH301-705.5 Chemistry QD1-999 Payal Ganguly Bradley Toghill Shelly Pathak Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives
description	The aging of bone marrow (BM) remains a very imperative and alluring subject, with an ever-increasing interest among fellow scientists. A considerable amount of progress has been made in this field with the established ‘hallmarks of aging’ and continued efforts to investigate the age-related changes observed within the BM. Inflammaging is considered as a low-grade state of inflammation associated with aging, and whilst the possible mechanisms by which aging occurs are now largely understood, the processes leading to the underlying changes within aged BM remain elusive. The ability to identify these changes and detect such alterations at the genetic level are key to broadening the knowledgebase of aging BM. Next-generation sequencing (NGS) is an important molecular-level application presenting the ability to not only determine genomic base changes but provide transcriptional profiling (RNA-seq), as well as a high-throughput analysis of DNA–protein interactions (ChIP-seq). Utilising NGS to explore the genetic alterations occurring over the aging process within alterative cell types facilitates the comprehension of the molecular and cellular changes influencing the dynamics of aging BM. Thus, this review prospects the current landscape of BM aging and explores how NGS technology is currently being applied within this ever-expanding field of research.
format	article
author	Payal Ganguly Bradley Toghill Shelly Pathak
author_facet	Payal Ganguly Bradley Toghill Shelly Pathak
author_sort	Payal Ganguly
title	Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives
title_short	Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives
title_full	Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives
title_fullStr	Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives
title_full_unstemmed	Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives
title_sort	aging, bone marrow and next-generation sequencing (ngs): recent advances and future perspectives
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/db7fce73b3ee440fb6110df6e2975092
work_keys_str_mv	AT payalganguly agingbonemarrowandnextgenerationsequencingngsrecentadvancesandfutureperspectives AT bradleytoghill agingbonemarrowandnextgenerationsequencingngsrecentadvancesandfutureperspectives AT shellypathak agingbonemarrowandnextgenerationsequencingngsrecentadvancesandfutureperspectives
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Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives

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