Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging

Abstract The human cochlea transforms sound waves into electrical signals in the acoustic nerve fibers with high acuity. This transformation occurs via vibrating anisotropic membranes (basilar and tectorial membranes) and frequency-specific hair cell receptors. Frequency-positions can be mapped with...

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Autores principales:	Hao Li, Luke Helpard, Jonas Ekeroot, Seyed Alireza Rohani, Ning Zhu, Helge Rask-Andersen, Hanif M. Ladak, Sumit Agrawal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db803eafe12944599f1cbd5b4e42650e
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spelling	oai:doaj.org-article:db803eafe12944599f1cbd5b4e42650e2021-12-02T15:54:02ZThree-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging10.1038/s41598-021-83225-w2045-2322https://doaj.org/article/db803eafe12944599f1cbd5b4e42650e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83225-whttps://doaj.org/toc/2045-2322Abstract The human cochlea transforms sound waves into electrical signals in the acoustic nerve fibers with high acuity. This transformation occurs via vibrating anisotropic membranes (basilar and tectorial membranes) and frequency-specific hair cell receptors. Frequency-positions can be mapped within the cochlea to create a tonotopic chart which fits an almost-exponential function with lowest frequencies positioned apically and highest frequencies positioned at the cochlear base (Bekesy 1960, Greenwood 1961). To date, models of frequency positions have been based on a two-dimensional analysis with inaccurate representations of the cochlear hook region. In the present study, the first three-dimensional frequency analysis of the cochlea using dendritic mapping to obtain accurate tonotopic maps of the human basilar membrane/organ of Corti and the spiral ganglion was performed. A novel imaging technique, synchrotron radiation phase-contrast imaging, was used and a spiral ganglion frequency function was estimated by nonlinear least squares fitting a Greenwood-like function (F = A (10 ax − K)) to the data. The three-dimensional tonotopic data presented herein has large implications for validating electrode position and creating customized frequency maps for cochlear implant recipients.Hao LiLuke HelpardJonas EkerootSeyed Alireza RohaniNing ZhuHelge Rask-AndersenHanif M. LadakSumit AgrawalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao Li Luke Helpard Jonas Ekeroot Seyed Alireza Rohani Ning Zhu Helge Rask-Andersen Hanif M. Ladak Sumit Agrawal Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
description	Abstract The human cochlea transforms sound waves into electrical signals in the acoustic nerve fibers with high acuity. This transformation occurs via vibrating anisotropic membranes (basilar and tectorial membranes) and frequency-specific hair cell receptors. Frequency-positions can be mapped within the cochlea to create a tonotopic chart which fits an almost-exponential function with lowest frequencies positioned apically and highest frequencies positioned at the cochlear base (Bekesy 1960, Greenwood 1961). To date, models of frequency positions have been based on a two-dimensional analysis with inaccurate representations of the cochlear hook region. In the present study, the first three-dimensional frequency analysis of the cochlea using dendritic mapping to obtain accurate tonotopic maps of the human basilar membrane/organ of Corti and the spiral ganglion was performed. A novel imaging technique, synchrotron radiation phase-contrast imaging, was used and a spiral ganglion frequency function was estimated by nonlinear least squares fitting a Greenwood-like function (F = A (10 ax − K)) to the data. The three-dimensional tonotopic data presented herein has large implications for validating electrode position and creating customized frequency maps for cochlear implant recipients.
format	article
author	Hao Li Luke Helpard Jonas Ekeroot Seyed Alireza Rohani Ning Zhu Helge Rask-Andersen Hanif M. Ladak Sumit Agrawal
author_facet	Hao Li Luke Helpard Jonas Ekeroot Seyed Alireza Rohani Ning Zhu Helge Rask-Andersen Hanif M. Ladak Sumit Agrawal
author_sort	Hao Li
title	Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
title_short	Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
title_full	Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
title_fullStr	Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
title_full_unstemmed	Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
title_sort	three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db803eafe12944599f1cbd5b4e42650e
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_version_	1718385480572076032

Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging

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