Appetite Regulation of TLR4-Induced Inflammatory Signaling

Appetite is the basis for obtaining food and maintaining normal metabolism. Toll-like receptor 4 (TLR4) is an important receptor expressed in the brain that induces inflammatory signaling after activation. Inflammation is considered to affect the homeostatic and non-homeostatic systems of appetite,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yongxiang Li, Qingyan Jiang, Lina Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TLR4 inflammation hypothalamus dopamine system SFAs Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/db856b9176084a1aa63bd6ade7f44188
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:db856b9176084a1aa63bd6ade7f44188
record_format	dspace
spelling	oai:doaj.org-article:db856b9176084a1aa63bd6ade7f441882021-12-01T08:30:21ZAppetite Regulation of TLR4-Induced Inflammatory Signaling1664-239210.3389/fendo.2021.777997https://doaj.org/article/db856b9176084a1aa63bd6ade7f441882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.777997/fullhttps://doaj.org/toc/1664-2392Appetite is the basis for obtaining food and maintaining normal metabolism. Toll-like receptor 4 (TLR4) is an important receptor expressed in the brain that induces inflammatory signaling after activation. Inflammation is considered to affect the homeostatic and non-homeostatic systems of appetite, which are dominated by hypothalamic and mesolimbic dopamine signaling. Although the pathological features of many types of inflammation are known, their physiological functions in appetite are largely unknown. This review mainly addresses several key issues, including the structures of the homeostatic and non-homeostatic systems. In addition, the mechanism by which TLR4-induced inflammatory signaling contributes to these two systems to regulate appetite is also discussed. This review will provide potential opportunities to develop new therapeutic interventions that control appetite under inflammatory conditions.Yongxiang LiYongxiang LiYongxiang LiQingyan JiangQingyan JiangLina WangLina WangFrontiers Media S.A.articleTLR4inflammationhypothalamusdopamine systemSFAsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TLR4 inflammation hypothalamus dopamine system SFAs Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	TLR4 inflammation hypothalamus dopamine system SFAs Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yongxiang Li Yongxiang Li Yongxiang Li Qingyan Jiang Qingyan Jiang Lina Wang Lina Wang Appetite Regulation of TLR4-Induced Inflammatory Signaling
description	Appetite is the basis for obtaining food and maintaining normal metabolism. Toll-like receptor 4 (TLR4) is an important receptor expressed in the brain that induces inflammatory signaling after activation. Inflammation is considered to affect the homeostatic and non-homeostatic systems of appetite, which are dominated by hypothalamic and mesolimbic dopamine signaling. Although the pathological features of many types of inflammation are known, their physiological functions in appetite are largely unknown. This review mainly addresses several key issues, including the structures of the homeostatic and non-homeostatic systems. In addition, the mechanism by which TLR4-induced inflammatory signaling contributes to these two systems to regulate appetite is also discussed. This review will provide potential opportunities to develop new therapeutic interventions that control appetite under inflammatory conditions.
format	article
author	Yongxiang Li Yongxiang Li Yongxiang Li Qingyan Jiang Qingyan Jiang Lina Wang Lina Wang
author_facet	Yongxiang Li Yongxiang Li Yongxiang Li Qingyan Jiang Qingyan Jiang Lina Wang Lina Wang
author_sort	Yongxiang Li
title	Appetite Regulation of TLR4-Induced Inflammatory Signaling
title_short	Appetite Regulation of TLR4-Induced Inflammatory Signaling
title_full	Appetite Regulation of TLR4-Induced Inflammatory Signaling
title_fullStr	Appetite Regulation of TLR4-Induced Inflammatory Signaling
title_full_unstemmed	Appetite Regulation of TLR4-Induced Inflammatory Signaling
title_sort	appetite regulation of tlr4-induced inflammatory signaling
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/db856b9176084a1aa63bd6ade7f44188
work_keys_str_mv	AT yongxiangli appetiteregulationoftlr4inducedinflammatorysignaling AT yongxiangli appetiteregulationoftlr4inducedinflammatorysignaling AT yongxiangli appetiteregulationoftlr4inducedinflammatorysignaling AT qingyanjiang appetiteregulationoftlr4inducedinflammatorysignaling AT qingyanjiang appetiteregulationoftlr4inducedinflammatorysignaling AT linawang appetiteregulationoftlr4inducedinflammatorysignaling AT linawang appetiteregulationoftlr4inducedinflammatorysignaling
_version_	1718405384010465280

Appetite Regulation of TLR4-Induced Inflammatory Signaling

Ejemplares similares