LOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS

The aim of present study was to determine the microbial pattern and a significance of local pustular immune factors for the progression of local pyogenic infection in surgical patients. To these purpose, specific infectious pathogens were identified and scored by means of conventional microbiologica...

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Autores principales:	K. V. Shmagel, N. A. Zubareva, A. V. Renzhin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	local immunity pyogenic infection cytokines immunoglobulins Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/db85c04d7bdf4279b76ad6b4ee3f5ec1
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id	oai:doaj.org-article:db85c04d7bdf4279b76ad6b4ee3f5ec1
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spelling	oai:doaj.org-article:db85c04d7bdf4279b76ad6b4ee3f5ec12021-11-18T08:03:38ZLOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS1563-06252313-741X10.15789/1563-0625-2010-4-5-393-398https://doaj.org/article/db85c04d7bdf4279b76ad6b4ee3f5ec12014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/213https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of present study was to determine the microbial pattern and a significance of local pustular immune factors for the progression of local pyogenic infection in surgical patients. To these purpose, specific infectious pathogens were identified and scored by means of conventional microbiological methods in the patients with pyogenic inflammatory diseases of skin and subcutaneous fat tissues. The numbers of purulent leukocytes were determined in the pustular exudates, and concentrations of TNFα, IL-1β, IL-8, IFN-γ, IL-4, IL-1ra, IgM, IgG, and IgA were measured in the samples, using enzyme immunoassay techniques. Appropriate parameters of effluents obtained from "clean" (non-infected) surgical lesions were taken as сontrols. It has been shown that Staphylococcus aureus plays a leading role in etiology of bacterial infections in our patients. The amounts of blood cells in pustular samples showed a direct and significant correlation with number of viable microorganisms derived from the effluent. Purulent wound exudates were characterized by high IL-1β and IL-8 concentrations, along with relatively low TNFα levels, as compared with "clean" wounds. Mean amounts of IgG in the pustular contents of dissected lesions proved to be five-fold higher that IgG levels in sterile incisions. As compared with young individuals, the elderly persons are characterized by lesser TNFα production, as well as by more active IL-8 synthesis in the areas of bacterial inflammation. The indexes of local immunity show sufficient differences between the areas of suppurative inflammation and sterile wound lesions.K. V. ShmagelN. A. ZubarevaA. V. RenzhinSPb RAACIarticlelocal immunitypyogenic infectioncytokinesimmunoglobulinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 393-398 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	local immunity pyogenic infection cytokines immunoglobulins Immunologic diseases. Allergy RC581-607
spellingShingle	local immunity pyogenic infection cytokines immunoglobulins Immunologic diseases. Allergy RC581-607 K. V. Shmagel N. A. Zubareva A. V. Renzhin LOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS
description	The aim of present study was to determine the microbial pattern and a significance of local pustular immune factors for the progression of local pyogenic infection in surgical patients. To these purpose, specific infectious pathogens were identified and scored by means of conventional microbiological methods in the patients with pyogenic inflammatory diseases of skin and subcutaneous fat tissues. The numbers of purulent leukocytes were determined in the pustular exudates, and concentrations of TNFα, IL-1β, IL-8, IFN-γ, IL-4, IL-1ra, IgM, IgG, and IgA were measured in the samples, using enzyme immunoassay techniques. Appropriate parameters of effluents obtained from "clean" (non-infected) surgical lesions were taken as сontrols. It has been shown that Staphylococcus aureus plays a leading role in etiology of bacterial infections in our patients. The amounts of blood cells in pustular samples showed a direct and significant correlation with number of viable microorganisms derived from the effluent. Purulent wound exudates were characterized by high IL-1β and IL-8 concentrations, along with relatively low TNFα levels, as compared with "clean" wounds. Mean amounts of IgG in the pustular contents of dissected lesions proved to be five-fold higher that IgG levels in sterile incisions. As compared with young individuals, the elderly persons are characterized by lesser TNFα production, as well as by more active IL-8 synthesis in the areas of bacterial inflammation. The indexes of local immunity show sufficient differences between the areas of suppurative inflammation and sterile wound lesions.
format	article
author	K. V. Shmagel N. A. Zubareva A. V. Renzhin
author_facet	K. V. Shmagel N. A. Zubareva A. V. Renzhin
author_sort	K. V. Shmagel
title	LOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS
title_short	LOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS
title_full	LOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS
title_fullStr	LOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS
title_full_unstemmed	LOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS
title_sort	local immunity patterns in purulent wounds
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/db85c04d7bdf4279b76ad6b4ee3f5ec1
work_keys_str_mv	AT kvshmagel localimmunitypatternsinpurulentwounds AT nazubareva localimmunitypatternsinpurulentwounds AT avrenzhin localimmunitypatternsinpurulentwounds
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LOCAL IMMUNITY PATTERNS IN PURULENT WOUNDS

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