Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy

Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy

Although paclitaxel is widely used as a chemotherapy, it suffers from poor solubility and toxicity issues. Here, the authors develop thermostable RNA nanoparticles and report the RNA-paclitaxel complex to display improved stability, drug loading capacity and solubility for improved targeted cancer t...

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Autores principales: Sijin Guo, Mario Vieweger, Kaiming Zhang, Hongran Yin, Hongzhi Wang, Xin Li, Shanshan Li, Shuiying Hu, Alex Sparreboom, B. Mark Evers, Yizhou Dong, Wah Chiu, Peixuan Guo
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/db868a87fc9b4ea6a3135743c4926948
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spelling oai:doaj.org-article:db868a87fc9b4ea6a3135743c49269482021-12-02T15:39:20ZUltra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy10.1038/s41467-020-14780-52041-1723https://doaj.org/article/db868a87fc9b4ea6a3135743c49269482020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14780-5https://doaj.org/toc/2041-1723Although paclitaxel is widely used as a chemotherapy, it suffers from poor solubility and toxicity issues. Here, the authors develop thermostable RNA nanoparticles and report the RNA-paclitaxel complex to display improved stability, drug loading capacity and solubility for improved targeted cancer therapy and reduced immune responses.Sijin GuoMario ViewegerKaiming ZhangHongran YinHongzhi WangXin LiShanshan LiShuiying HuAlex SparreboomB. Mark EversYizhou DongWah ChiuPeixuan GuoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sijin Guo
Mario Vieweger
Kaiming Zhang
Hongran Yin
Hongzhi Wang
Xin Li
Shanshan Li
Shuiying Hu
Alex Sparreboom
B. Mark Evers
Yizhou Dong
Wah Chiu
Peixuan Guo
Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
description Although paclitaxel is widely used as a chemotherapy, it suffers from poor solubility and toxicity issues. Here, the authors develop thermostable RNA nanoparticles and report the RNA-paclitaxel complex to display improved stability, drug loading capacity and solubility for improved targeted cancer therapy and reduced immune responses.
format article
author Sijin Guo
Mario Vieweger
Kaiming Zhang
Hongran Yin
Hongzhi Wang
Xin Li
Shanshan Li
Shuiying Hu
Alex Sparreboom
B. Mark Evers
Yizhou Dong
Wah Chiu
Peixuan Guo
author_facet Sijin Guo
Mario Vieweger
Kaiming Zhang
Hongran Yin
Hongzhi Wang
Xin Li
Shanshan Li
Shuiying Hu
Alex Sparreboom
B. Mark Evers
Yizhou Dong
Wah Chiu
Peixuan Guo
author_sort Sijin Guo
title Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
title_short Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
title_full Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
title_fullStr Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
title_full_unstemmed Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
title_sort ultra-thermostable rna nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/db868a87fc9b4ea6a3135743c4926948
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