Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults

Postprandial macro- and microvascular blood flow and metabolic dysfunction manifest with advancing age, so vascular transmuting interventions are desirable. In this randomised, single-blind, placebo-controlled, crossover trial, we investigated the impact of the acute administration of green tea extr...

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Autores principales:	Ushnah S. U. Din, Tanvir S. Sian, Colleen S. Deane, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Philip J. Atherton, Bethan E. Phillips
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	green tea extract epigallocatechin-3-gallate blood flow glucose metabolism skeletal muscle Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/db8a9a31313644b8b4504b71f2a14193
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spelling	oai:doaj.org-article:db8a9a31313644b8b4504b71f2a141932021-11-25T18:35:02ZGreen Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults10.3390/nu131138952072-6643https://doaj.org/article/db8a9a31313644b8b4504b71f2a141932021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3895https://doaj.org/toc/2072-6643Postprandial macro- and microvascular blood flow and metabolic dysfunction manifest with advancing age, so vascular transmuting interventions are desirable. In this randomised, single-blind, placebo-controlled, crossover trial, we investigated the impact of the acute administration of green tea extract (GTE; containing ~500 mg epigallocatechin-3-gallate) versus placebo (CON), alongside an oral nutritional supplement (ONS), on muscle macro- and microvascular, cerebral macrovascular (via ultrasound) and leg glucose/insulin metabolic responses (via arterialised/venous blood samples) in twelve healthy older adults (42% male, 74 ± 1 y). GTE increased <i>m. vastus lateralis</i> microvascular blood volume (MBV) at 180 and 240 min after ONS (baseline: 1.0 vs. 180 min: 1.11 ± 0.02 vs. 240 min: 1.08 ± 0.04, both <i>p</i> < 0.005), with MBV significantly higher than CON at 180 min (<i>p</i> < 0.05). Neither the ONS nor the GTE impacted <i>m. tibialis anterior</i> perfusion (<i>p</i> > 0.05). Leg blood flow and vascular conductance increased, and vascular resistance decreased similarly in both conditions (<i>p</i> < 0.05). Small non-significant increases in brachial artery flow-mediated dilation were observed in the GTE only and middle cerebral artery blood flow did not change in response to GTE or CON (<i>p</i> > 0.05). Glucose uptake increased with the GTE only (0 min: 0.03 ± 0.01 vs. 35 min: 0.11 ± 0.02 mmol/min/leg, <i>p</i> = 0.007); however, glucose area under the curve and insulin kinetics were similar between conditions (<i>p</i> > 0.05). Acute GTE supplementation enhances MBV beyond the effects of an oral mixed meal, but this improved perfusion does not translate to increased leg muscle glucose uptake in healthy older adults.Ushnah S. U. DinTanvir S. SianColleen S. DeaneKen SmithAmanda GatesJonathan N. LundJohn P. WilliamsRicardo RuedaSuzette L. PereiraPhilip J. AthertonBethan E. PhillipsMDPI AGarticlegreen tea extractepigallocatechin-3-gallateblood flowglucose metabolismskeletal muscleNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3895, p 3895 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	green tea extract epigallocatechin-3-gallate blood flow glucose metabolism skeletal muscle Nutrition. Foods and food supply TX341-641
spellingShingle	green tea extract epigallocatechin-3-gallate blood flow glucose metabolism skeletal muscle Nutrition. Foods and food supply TX341-641 Ushnah S. U. Din Tanvir S. Sian Colleen S. Deane Ken Smith Amanda Gates Jonathan N. Lund John P. Williams Ricardo Rueda Suzette L. Pereira Philip J. Atherton Bethan E. Phillips Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults
description	Postprandial macro- and microvascular blood flow and metabolic dysfunction manifest with advancing age, so vascular transmuting interventions are desirable. In this randomised, single-blind, placebo-controlled, crossover trial, we investigated the impact of the acute administration of green tea extract (GTE; containing ~500 mg epigallocatechin-3-gallate) versus placebo (CON), alongside an oral nutritional supplement (ONS), on muscle macro- and microvascular, cerebral macrovascular (via ultrasound) and leg glucose/insulin metabolic responses (via arterialised/venous blood samples) in twelve healthy older adults (42% male, 74 ± 1 y). GTE increased <i>m. vastus lateralis</i> microvascular blood volume (MBV) at 180 and 240 min after ONS (baseline: 1.0 vs. 180 min: 1.11 ± 0.02 vs. 240 min: 1.08 ± 0.04, both <i>p</i> < 0.005), with MBV significantly higher than CON at 180 min (<i>p</i> < 0.05). Neither the ONS nor the GTE impacted <i>m. tibialis anterior</i> perfusion (<i>p</i> > 0.05). Leg blood flow and vascular conductance increased, and vascular resistance decreased similarly in both conditions (<i>p</i> < 0.05). Small non-significant increases in brachial artery flow-mediated dilation were observed in the GTE only and middle cerebral artery blood flow did not change in response to GTE or CON (<i>p</i> > 0.05). Glucose uptake increased with the GTE only (0 min: 0.03 ± 0.01 vs. 35 min: 0.11 ± 0.02 mmol/min/leg, <i>p</i> = 0.007); however, glucose area under the curve and insulin kinetics were similar between conditions (<i>p</i> > 0.05). Acute GTE supplementation enhances MBV beyond the effects of an oral mixed meal, but this improved perfusion does not translate to increased leg muscle glucose uptake in healthy older adults.
format	article
author	Ushnah S. U. Din Tanvir S. Sian Colleen S. Deane Ken Smith Amanda Gates Jonathan N. Lund John P. Williams Ricardo Rueda Suzette L. Pereira Philip J. Atherton Bethan E. Phillips
author_facet	Ushnah S. U. Din Tanvir S. Sian Colleen S. Deane Ken Smith Amanda Gates Jonathan N. Lund John P. Williams Ricardo Rueda Suzette L. Pereira Philip J. Atherton Bethan E. Phillips
author_sort	Ushnah S. U. Din
title	Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults
title_short	Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults
title_full	Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults
title_fullStr	Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults
title_full_unstemmed	Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults
title_sort	green tea extract concurrent with an oral nutritional supplement acutely enhances muscle microvascular blood flow without altering leg glucose uptake in healthy older adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/db8a9a31313644b8b4504b71f2a14193
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Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults

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