Evolution of default genetic control mechanisms.

We present a model of the evolution of control systems in a genome under environmental constraints. The model conceptually follows the Jacob and Monod model of gene control. Genes contain control elements which respond to the internal state of the cell as well as the environment to control expressio...

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Autores principales:	William Bains, Enrico Borriello, Dirk Schulze-Makuch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db8dee6264fe4dcb94f466e9e130ee71
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id	oai:doaj.org-article:db8dee6264fe4dcb94f466e9e130ee71
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spelling	oai:doaj.org-article:db8dee6264fe4dcb94f466e9e130ee712021-12-02T20:04:02ZEvolution of default genetic control mechanisms.1932-620310.1371/journal.pone.0251568https://doaj.org/article/db8dee6264fe4dcb94f466e9e130ee712021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251568https://doaj.org/toc/1932-6203We present a model of the evolution of control systems in a genome under environmental constraints. The model conceptually follows the Jacob and Monod model of gene control. Genes contain control elements which respond to the internal state of the cell as well as the environment to control expression of a coding region. Control and coding regions evolve to maximize a fitness function between expressed coding sequences and the environment. The model was run 118 times to an average of 1.4∙106 'generations' each with a range of starting parameters probed the conditions under which genomes evolved a 'default style' of control. Unexpectedly, the control logic that evolved was not significantly correlated to the complexity of the environment. Genetic logic was strongly correlated with genome complexity and with the fraction of genes active in the cell at any one time. More complex genomes correlated with the evolution of genetic controls in which genes were active ('default on'), and a low fraction of genes being expressed correlated with a genetic logic in which genes were biased to being inactive unless positively activated ('default off' logic). We discuss how this might relate to the evolution of the complex eukaryotic genome, which operates in a 'default off' mode.William BainsEnrico BorrielloDirk Schulze-MakuchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251568 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q William Bains Enrico Borriello Dirk Schulze-Makuch Evolution of default genetic control mechanisms.
description	We present a model of the evolution of control systems in a genome under environmental constraints. The model conceptually follows the Jacob and Monod model of gene control. Genes contain control elements which respond to the internal state of the cell as well as the environment to control expression of a coding region. Control and coding regions evolve to maximize a fitness function between expressed coding sequences and the environment. The model was run 118 times to an average of 1.4∙106 'generations' each with a range of starting parameters probed the conditions under which genomes evolved a 'default style' of control. Unexpectedly, the control logic that evolved was not significantly correlated to the complexity of the environment. Genetic logic was strongly correlated with genome complexity and with the fraction of genes active in the cell at any one time. More complex genomes correlated with the evolution of genetic controls in which genes were active ('default on'), and a low fraction of genes being expressed correlated with a genetic logic in which genes were biased to being inactive unless positively activated ('default off' logic). We discuss how this might relate to the evolution of the complex eukaryotic genome, which operates in a 'default off' mode.
format	article
author	William Bains Enrico Borriello Dirk Schulze-Makuch
author_facet	William Bains Enrico Borriello Dirk Schulze-Makuch
author_sort	William Bains
title	Evolution of default genetic control mechanisms.
title_short	Evolution of default genetic control mechanisms.
title_full	Evolution of default genetic control mechanisms.
title_fullStr	Evolution of default genetic control mechanisms.
title_full_unstemmed	Evolution of default genetic control mechanisms.
title_sort	evolution of default genetic control mechanisms.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/db8dee6264fe4dcb94f466e9e130ee71
work_keys_str_mv	AT williambains evolutionofdefaultgeneticcontrolmechanisms AT enricoborriello evolutionofdefaultgeneticcontrolmechanisms AT dirkschulzemakuch evolutionofdefaultgeneticcontrolmechanisms
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Evolution of default genetic control mechanisms.

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