Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery

Yijie Hua,1,* Lan Chen,1,* Chenxi Hou,2 Shengbo Liu,3 Zhichao Pei,2 Yuchao Lu1 1Analysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of China; 2College of Chemistry & Pharmacy, Shaanxi Key Laboratory of...

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Autores principales:	Hua Y, Chen L, Hou C, Liu S, Pei Z, Lu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	supramolecular vesicles amphiphilic pillar[n]arenes smart drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/db8e7b6542374ae8a099475fdc3177a1
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spelling	oai:doaj.org-article:db8e7b6542374ae8a099475fdc3177a12021-12-02T12:24:21ZSupramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery1178-2013https://doaj.org/article/db8e7b6542374ae8a099475fdc3177a12020-08-01T00:00:00Zhttps://www.dovepress.com/supramolecular-vesicles-based-on-amphiphilic-pillarnarenes-for-smart-n-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yijie Hua,1,* Lan Chen,1,* Chenxi Hou,2 Shengbo Liu,3 Zhichao Pei,2 Yuchao Lu1 1Analysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of China; 2College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China; 3School of Chemistry, Biology, and Material Engineering, Suzhou University of Science and Technology, Suzhou, Jiangsu 215009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuchao LuAnalysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of ChinaTel/ Fax +86 317 560 5226Email luyuchao@hebau.edu.cnZhichao PeiCollege of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of ChinaTel +86 298 709 1196Fax +86 298 709 2769Email peizc@nwafu.edu.cnAbstract: Supramolecular vesicles are the most popular smart nano-drug delivery systems (SDDs) because of their unique cavities, which have high loading carrying capacity and controlled-release action in response to specific stimuli. These vesicles are constructed from amphiphilic molecules via host-guest complexation, typically with targeted stimuli-responsive units, which are particularly important in biotechnology and biomedicine applications. Amphiphilic pillar[n]arenes, which are novel and functional macrocyclic host molecules, have been widely used to construct supramolecular vesicles because of their intrinsic rigid and symmetrical structure, electron-rich cavities and excellent properties. In this review, we first explain the synthesis of three types of amphiphilic pillar[n]arenes: neutral, anionic and cationic pillar[n]arenes. Second, we examine supramolecular vesicles composed of amphiphilic pillar[n]arenes recently used for the construction of SDDs. In addition, we describe the prospects for multifunctional amphiphilic pillar[n]arenes, particularly their potential in novel applications.Keywords: supramolecular vesicles, amphiphilic pillar[n]arenes, smart, drug deliveryHua YChen LHou CLiu SPei ZLu YDove Medical Pressarticlesupramolecular vesiclesamphiphilic pillar[n]arenessmartdrug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 5873-5899 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	supramolecular vesicles amphiphilic pillar[n]arenes smart drug delivery Medicine (General) R5-920
spellingShingle	supramolecular vesicles amphiphilic pillar[n]arenes smart drug delivery Medicine (General) R5-920 Hua Y Chen L Hou C Liu S Pei Z Lu Y Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery
description	Yijie Hua,1,* Lan Chen,1,* Chenxi Hou,2 Shengbo Liu,3 Zhichao Pei,2 Yuchao Lu1 1Analysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of China; 2College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China; 3School of Chemistry, Biology, and Material Engineering, Suzhou University of Science and Technology, Suzhou, Jiangsu 215009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuchao LuAnalysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of ChinaTel/ Fax +86 317 560 5226Email luyuchao@hebau.edu.cnZhichao PeiCollege of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of ChinaTel +86 298 709 1196Fax +86 298 709 2769Email peizc@nwafu.edu.cnAbstract: Supramolecular vesicles are the most popular smart nano-drug delivery systems (SDDs) because of their unique cavities, which have high loading carrying capacity and controlled-release action in response to specific stimuli. These vesicles are constructed from amphiphilic molecules via host-guest complexation, typically with targeted stimuli-responsive units, which are particularly important in biotechnology and biomedicine applications. Amphiphilic pillar[n]arenes, which are novel and functional macrocyclic host molecules, have been widely used to construct supramolecular vesicles because of their intrinsic rigid and symmetrical structure, electron-rich cavities and excellent properties. In this review, we first explain the synthesis of three types of amphiphilic pillar[n]arenes: neutral, anionic and cationic pillar[n]arenes. Second, we examine supramolecular vesicles composed of amphiphilic pillar[n]arenes recently used for the construction of SDDs. In addition, we describe the prospects for multifunctional amphiphilic pillar[n]arenes, particularly their potential in novel applications.Keywords: supramolecular vesicles, amphiphilic pillar[n]arenes, smart, drug delivery
format	article
author	Hua Y Chen L Hou C Liu S Pei Z Lu Y
author_facet	Hua Y Chen L Hou C Liu S Pei Z Lu Y
author_sort	Hua Y
title	Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery
title_short	Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery
title_full	Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery
title_fullStr	Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery
title_full_unstemmed	Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery
title_sort	supramolecular vesicles based on amphiphilic pillar[n]arenes for smart nano-drug delivery
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/db8e7b6542374ae8a099475fdc3177a1
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Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery

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