Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats
Objective: Diabetes mellitus is a metabolic disease due to failure in insulin secretion function. Kidney is a target organ in diabetes. Diabetic nephropathy is a major cause of end stage renal disease and resulting in increased morbidity and mortality of affected individuals. Since diabetes is a pro...
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Babol University of Medical Sciences
2000
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oai:doaj.org-article:db904f8c782c40c2b16a24b97707fa6a2021-11-10T09:21:59ZDetection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats1561-41072251-7170https://doaj.org/article/db904f8c782c40c2b16a24b97707fa6a2000-01-01T00:00:00Zhttp://jbums.org/article-1-2927-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Diabetes mellitus is a metabolic disease due to failure in insulin secretion function. Kidney is a target organ in diabetes. Diabetic nephropathy is a major cause of end stage renal disease and resulting in increased morbidity and mortality of affected individuals. Since diabetes is a progressive disease, early diagnosis serves better treatment. Methods: We induced diabetes in rat by alloxan administration after 8 weeks. We detected lipofuscin products with H;E, PAS and schmorl’s staining methods. Findings: Diabetic rats showed increasing lipofuscin in renal proximal tubular cells. Conclusion: Increased lipofuscin pigments is a good indicator for diagnosis of diabetes in rats.M Pour GhasemM JalaliM NikraveshM Behnam RasoliN AminianBabol University of Medical Sciencesarticlediabetes mellituslipofuscinalloxankidneyMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 2, Iss 1, Pp 15-20 (2000) |
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EN FA |
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diabetes mellitus lipofuscin alloxan kidney Medicine R Medicine (General) R5-920 |
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diabetes mellitus lipofuscin alloxan kidney Medicine R Medicine (General) R5-920 M Pour Ghasem M Jalali M Nikravesh M Behnam Rasoli N Aminian Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats |
| description |
Objective: Diabetes mellitus is a metabolic disease due to failure in insulin secretion function. Kidney is a target organ in diabetes. Diabetic nephropathy is a major cause of end stage renal disease and resulting in increased morbidity and mortality of affected individuals. Since diabetes is a progressive disease, early diagnosis serves better treatment. Methods: We induced diabetes in rat by alloxan administration after 8 weeks. We detected lipofuscin products with H;E, PAS and schmorl’s staining methods. Findings: Diabetic rats showed increasing lipofuscin in renal proximal tubular cells. Conclusion: Increased lipofuscin pigments is a good indicator for diagnosis of diabetes in rats. |
| format |
article |
| author |
M Pour Ghasem M Jalali M Nikravesh M Behnam Rasoli N Aminian |
| author_facet |
M Pour Ghasem M Jalali M Nikravesh M Behnam Rasoli N Aminian |
| author_sort |
M Pour Ghasem |
| title |
Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats |
| title_short |
Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats |
| title_full |
Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats |
| title_fullStr |
Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats |
| title_full_unstemmed |
Detection of Alloxan induced Lipofuscin pigmentation in the cells of renal tubule of diabetic rats |
| title_sort |
detection of alloxan induced lipofuscin pigmentation in the cells of renal tubule of diabetic rats |
| publisher |
Babol University of Medical Sciences |
| publishDate |
2000 |
| url |
https://doaj.org/article/db904f8c782c40c2b16a24b97707fa6a |
| work_keys_str_mv |
AT mpourghasem detectionofalloxaninducedlipofuscinpigmentationinthecellsofrenaltubuleofdiabeticrats AT mjalali detectionofalloxaninducedlipofuscinpigmentationinthecellsofrenaltubuleofdiabeticrats AT mnikravesh detectionofalloxaninducedlipofuscinpigmentationinthecellsofrenaltubuleofdiabeticrats AT mbehnamrasoli detectionofalloxaninducedlipofuscinpigmentationinthecellsofrenaltubuleofdiabeticrats AT naminian detectionofalloxaninducedlipofuscinpigmentationinthecellsofrenaltubuleofdiabeticrats |
| _version_ |
1718440145539039232 |