Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

Vaccination against neo-antigens has resulted in an effective antitumor response in several models. Here, the authors show that delivery of larger sets of neo-antigens using an adenovirus-based vaccination platform, results in much better tumor protection when combined with checkpoint blockade in a...

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Autores principales:	Anna Morena D’Alise, Guido Leoni, Gabriella Cotugno, Fulvia Troise, Francesca Langone, Imma Fichera, Maria De Lucia, Lidia Avalle, Rosa Vitale, Adriano Leuzzi, Veronica Bignone, Elena Di Matteo, Fabio Giovanni Tucci, Valeria Poli, Armin Lahm, Maria Teresa Catanese, Antonella Folgori, Stefano Colloca, Alfredo Nicosia, Elisa Scarselli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db93e80d193c417e9e00b2880fe30cbc
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spelling	oai:doaj.org-article:db93e80d193c417e9e00b2880fe30cbc2021-12-02T17:02:16ZAdenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade10.1038/s41467-019-10594-22041-1723https://doaj.org/article/db93e80d193c417e9e00b2880fe30cbc2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10594-2https://doaj.org/toc/2041-1723Vaccination against neo-antigens has resulted in an effective antitumor response in several models. Here, the authors show that delivery of larger sets of neo-antigens using an adenovirus-based vaccination platform, results in much better tumor protection when combined with checkpoint blockade in a mouse model of advanced disease.Anna Morena D’AliseGuido LeoniGabriella CotugnoFulvia TroiseFrancesca LangoneImma FicheraMaria De LuciaLidia AvalleRosa VitaleAdriano LeuzziVeronica BignoneElena Di MatteoFabio Giovanni TucciValeria PoliArmin LahmMaria Teresa CataneseAntonella FolgoriStefano CollocaAlfredo NicosiaElisa ScarselliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna Morena D’Alise Guido Leoni Gabriella Cotugno Fulvia Troise Francesca Langone Imma Fichera Maria De Lucia Lidia Avalle Rosa Vitale Adriano Leuzzi Veronica Bignone Elena Di Matteo Fabio Giovanni Tucci Valeria Poli Armin Lahm Maria Teresa Catanese Antonella Folgori Stefano Colloca Alfredo Nicosia Elisa Scarselli Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade
description	Vaccination against neo-antigens has resulted in an effective antitumor response in several models. Here, the authors show that delivery of larger sets of neo-antigens using an adenovirus-based vaccination platform, results in much better tumor protection when combined with checkpoint blockade in a mouse model of advanced disease.
format	article
author	Anna Morena D’Alise Guido Leoni Gabriella Cotugno Fulvia Troise Francesca Langone Imma Fichera Maria De Lucia Lidia Avalle Rosa Vitale Adriano Leuzzi Veronica Bignone Elena Di Matteo Fabio Giovanni Tucci Valeria Poli Armin Lahm Maria Teresa Catanese Antonella Folgori Stefano Colloca Alfredo Nicosia Elisa Scarselli
author_facet	Anna Morena D’Alise Guido Leoni Gabriella Cotugno Fulvia Troise Francesca Langone Imma Fichera Maria De Lucia Lidia Avalle Rosa Vitale Adriano Leuzzi Veronica Bignone Elena Di Matteo Fabio Giovanni Tucci Valeria Poli Armin Lahm Maria Teresa Catanese Antonella Folgori Stefano Colloca Alfredo Nicosia Elisa Scarselli
author_sort	Anna Morena D’Alise
title	Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade
title_short	Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade
title_full	Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade
title_fullStr	Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade
title_full_unstemmed	Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade
title_sort	adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/db93e80d193c417e9e00b2880fe30cbc
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Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

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