The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline

Kamal A Amin1, Mohamed S Hassan2, El-Said T Awad3, Khalid S Hashem11Department of Biochemistry, 2Department of Internal Medicine, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt; 3Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Cairo, EgyptObjecti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kamal A Amin, Mohamed S Hassan, El-Said T Awad, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/db96bb2b5b8c41c7b4af644485c5c854
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:db96bb2b5b8c41c7b4af644485c5c854
record_format	dspace
spelling	oai:doaj.org-article:db96bb2b5b8c41c7b4af644485c5c8542021-12-02T02:35:14ZThe protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline1176-91141178-2013https://doaj.org/article/db96bb2b5b8c41c7b4af644485c5c8542011-01-01T00:00:00Zhttp://www.dovepress.com/the-protective-effects-of-cerium-oxide-nanoparticles-against-hepatic-o-a6072https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Kamal A Amin1, Mohamed S Hassan2, El-Said T Awad3, Khalid S Hashem11Department of Biochemistry, 2Department of Internal Medicine, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt; 3Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Cairo, EgyptObjective: The objective of the present study was to determine the ability of cerium oxide (CeO2) nanoparticles to protect against monocrotaline (MCT)-induced hepatotoxicity in a rat model.Method: Twenty male Sprague Dawley rats were arbitrarily assigned to four groups: control (received saline), CeO2 (given 0.0001 nmol/kg intraperitoneally [IP]), MCT (given 10 mg/kg body weight IP as a single dose), and MCT + CeO2 (received CeO2 both before and after MCT). Electron microscopic imaging of the rat livers was carried out, and hepatic total glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPX), glutathione S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) enzymatic activities were quantified.Results: Results showed a significant MCT-induced decrease in total hepatic GSH, GPX, GR, and GST normalized to control values with concurrent CeO2 administration. In addition, MCT produced significant increases in hepatic CAT and SOD activities, which also ameliorated with CeO2.Conclusions: These results indicate that CeO2 acts as a putative novel and effective hepatoprotective agent against MCT-induced hepatotoxicity.Keywords: monocrotaline, ceruim oxide nanoparticle, hepatotoxicity, oxidative stress Kamal A AminMohamed S HassanEl-Said T Awadet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 143-149 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kamal A Amin Mohamed S Hassan El-Said T Awad et al The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
description	Kamal A Amin1, Mohamed S Hassan2, El-Said T Awad3, Khalid S Hashem11Department of Biochemistry, 2Department of Internal Medicine, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt; 3Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Cairo, EgyptObjective: The objective of the present study was to determine the ability of cerium oxide (CeO2) nanoparticles to protect against monocrotaline (MCT)-induced hepatotoxicity in a rat model.Method: Twenty male Sprague Dawley rats were arbitrarily assigned to four groups: control (received saline), CeO2 (given 0.0001 nmol/kg intraperitoneally [IP]), MCT (given 10 mg/kg body weight IP as a single dose), and MCT + CeO2 (received CeO2 both before and after MCT). Electron microscopic imaging of the rat livers was carried out, and hepatic total glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPX), glutathione S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) enzymatic activities were quantified.Results: Results showed a significant MCT-induced decrease in total hepatic GSH, GPX, GR, and GST normalized to control values with concurrent CeO2 administration. In addition, MCT produced significant increases in hepatic CAT and SOD activities, which also ameliorated with CeO2.Conclusions: These results indicate that CeO2 acts as a putative novel and effective hepatoprotective agent against MCT-induced hepatotoxicity.Keywords: monocrotaline, ceruim oxide nanoparticle, hepatotoxicity, oxidative stress
format	article
author	Kamal A Amin Mohamed S Hassan El-Said T Awad et al
author_facet	Kamal A Amin Mohamed S Hassan El-Said T Awad et al
author_sort	Kamal A Amin
title	The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
title_short	The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
title_full	The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
title_fullStr	The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
title_full_unstemmed	The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
title_sort	protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/db96bb2b5b8c41c7b4af644485c5c854
work_keys_str_mv	AT kamalaamin theprotectiveeffectsofceriumoxidenanoparticlesagainsthepaticoxidativedamageinducedbymonocrotaline AT mohamedshassan theprotectiveeffectsofceriumoxidenanoparticlesagainsthepaticoxidativedamageinducedbymonocrotaline AT elsaidtawad theprotectiveeffectsofceriumoxidenanoparticlesagainsthepaticoxidativedamageinducedbymonocrotaline AT etal theprotectiveeffectsofceriumoxidenanoparticlesagainsthepaticoxidativedamageinducedbymonocrotaline AT kamalaamin protectiveeffectsofceriumoxidenanoparticlesagainsthepaticoxidativedamageinducedbymonocrotaline AT mohamedshassan protectiveeffectsofceriumoxidenanoparticlesagainsthepaticoxidativedamageinducedbymonocrotaline AT elsaidtawad protectiveeffectsofceriumoxidenanoparticlesagainsthepaticoxidativedamageinducedbymonocrotaline AT etal protectiveeffectsofceriumoxidenanoparticlesagainsthepaticoxidativedamageinducedbymonocrotaline
_version_	1718402379867488256

The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline

Ejemplares similares