Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro

Influenza viruses cause respiratory tract infections and substantial health concerns. Infection may result in mild to severe respiratory disease associated with morbidity and some mortality. Several anti-influenza drugs are available, but these agents target viral components and are susceptible to d...

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Autores principales:	Nichole Orr-Burks, Jackelyn Murray, Kyle V. Todd, Abhijeet Bakre, Ralph A. Tripp
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db9893bc49e642808a469b76e5972373
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spelling	oai:doaj.org-article:db9893bc49e642808a469b76e59723732021-11-04T07:42:09ZDrug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro1932-6203https://doaj.org/article/db9893bc49e642808a469b76e59723732021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555795/?tool=EBIhttps://doaj.org/toc/1932-6203Influenza viruses cause respiratory tract infections and substantial health concerns. Infection may result in mild to severe respiratory disease associated with morbidity and some mortality. Several anti-influenza drugs are available, but these agents target viral components and are susceptible to drug resistance. There is a need for new antiviral drug strategies that include repurposing of clinically approved drugs. Drugs that target cellular machinery necessary for influenza virus replication can provide a means for inhibiting influenza virus replication. We used RNA interference screening to identify key host cell genes required for influenza replication, and then FDA-approved drugs that could be repurposed for targeting host genes. We examined the effects of Clopidogrel and Triamterene to inhibit A/WSN/33 (EC50 5.84 uM and 31.48 uM, respectively), A/CA/04/09 (EC50 6.432 uM and 3.32 uM, respectively), and B/Yamagata/16/1988 (EC50 0.28 uM and 0.11 uM, respectively) replication. Clopidogrel and Triamterene provide a druggable approach to influenza treatment across multiple strains and subtypes.Nichole Orr-BurksJackelyn MurrayKyle V. ToddAbhijeet BakreRalph A. TrippPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nichole Orr-Burks Jackelyn Murray Kyle V. Todd Abhijeet Bakre Ralph A. Tripp Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro
description	Influenza viruses cause respiratory tract infections and substantial health concerns. Infection may result in mild to severe respiratory disease associated with morbidity and some mortality. Several anti-influenza drugs are available, but these agents target viral components and are susceptible to drug resistance. There is a need for new antiviral drug strategies that include repurposing of clinically approved drugs. Drugs that target cellular machinery necessary for influenza virus replication can provide a means for inhibiting influenza virus replication. We used RNA interference screening to identify key host cell genes required for influenza replication, and then FDA-approved drugs that could be repurposed for targeting host genes. We examined the effects of Clopidogrel and Triamterene to inhibit A/WSN/33 (EC50 5.84 uM and 31.48 uM, respectively), A/CA/04/09 (EC50 6.432 uM and 3.32 uM, respectively), and B/Yamagata/16/1988 (EC50 0.28 uM and 0.11 uM, respectively) replication. Clopidogrel and Triamterene provide a druggable approach to influenza treatment across multiple strains and subtypes.
format	article
author	Nichole Orr-Burks Jackelyn Murray Kyle V. Todd Abhijeet Bakre Ralph A. Tripp
author_facet	Nichole Orr-Burks Jackelyn Murray Kyle V. Todd Abhijeet Bakre Ralph A. Tripp
author_sort	Nichole Orr-Burks
title	Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro
title_short	Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro
title_full	Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro
title_fullStr	Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro
title_full_unstemmed	Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro
title_sort	drug repositioning of clopidogrel or triamterene to inhibit influenza virus replication in vitro
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/db9893bc49e642808a469b76e5972373
work_keys_str_mv	AT nicholeorrburks drugrepositioningofclopidogrelortriamterenetoinhibitinfluenzavirusreplicationinvitro AT jackelynmurray drugrepositioningofclopidogrelortriamterenetoinhibitinfluenzavirusreplicationinvitro AT kylevtodd drugrepositioningofclopidogrelortriamterenetoinhibitinfluenzavirusreplicationinvitro AT abhijeetbakre drugrepositioningofclopidogrelortriamterenetoinhibitinfluenzavirusreplicationinvitro AT ralphatripp drugrepositioningofclopidogrelortriamterenetoinhibitinfluenzavirusreplicationinvitro
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Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro

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