The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens

Abstract The characterization of molecular mechanisms underlying the taste-sensing system of chickens will add to our understanding of their feeding behaviors in poultry farming. In the mammalian taste system, the heterodimer of taste receptor type 1 members 1/3 (T1R1/T1R3) functions as an umami (am...

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Autores principales:	Yuta Yoshida, Fuminori Kawabata, Shotaro Nishimura, Shoji Tabata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/db98fdec813046ba9f48756d52d142f3
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spelling	oai:doaj.org-article:db98fdec813046ba9f48756d52d142f32021-12-02T17:30:34ZThe umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens10.1038/s41598-021-91728-92045-2322https://doaj.org/article/db98fdec813046ba9f48756d52d142f32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91728-9https://doaj.org/toc/2045-2322Abstract The characterization of molecular mechanisms underlying the taste-sensing system of chickens will add to our understanding of their feeding behaviors in poultry farming. In the mammalian taste system, the heterodimer of taste receptor type 1 members 1/3 (T1R1/T1R3) functions as an umami (amino acid) taste receptor. Here, we analyzed the expression patterns of T1R1 and T1R3 in the taste cells of chickens, labeled by the molecular markers for chicken taste buds (vimentin and α-gustducin). We observed that α-gustducin was expressed in some of the chicken T1R3-positive taste bud cells but rarely expressed in the T1R1-positive and T2R7-positive taste bud cells. These results raise the possibility that there is another second messenger signaling system in chicken taste sensory cells. We also observed that T1R3 and α-gustducin were expressed mostly in the vimentin-positive taste bud cells, whereas T1R1 and bitter taste receptor (i.e., taste receptor type 2 member 7, T2R7) were expressed largely in the vimentin-negative taste bud cells in chickens. In addition, we observed that T1R1 and T1R3 were co-expressed in about 5% of chickens' taste bud cells, which express T1R1 or T1R3. These results suggest that the heterodimer of T1R1 and T1R3 is rarely formed in chickens’ taste bud cells, and they provide comparative insights into the expressional regulation of taste receptors in the taste bud cells of vertebrates.Yuta YoshidaFuminori KawabataShotaro NishimuraShoji TabataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuta Yoshida Fuminori Kawabata Shotaro Nishimura Shoji Tabata The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
description	Abstract The characterization of molecular mechanisms underlying the taste-sensing system of chickens will add to our understanding of their feeding behaviors in poultry farming. In the mammalian taste system, the heterodimer of taste receptor type 1 members 1/3 (T1R1/T1R3) functions as an umami (amino acid) taste receptor. Here, we analyzed the expression patterns of T1R1 and T1R3 in the taste cells of chickens, labeled by the molecular markers for chicken taste buds (vimentin and α-gustducin). We observed that α-gustducin was expressed in some of the chicken T1R3-positive taste bud cells but rarely expressed in the T1R1-positive and T2R7-positive taste bud cells. These results raise the possibility that there is another second messenger signaling system in chicken taste sensory cells. We also observed that T1R3 and α-gustducin were expressed mostly in the vimentin-positive taste bud cells, whereas T1R1 and bitter taste receptor (i.e., taste receptor type 2 member 7, T2R7) were expressed largely in the vimentin-negative taste bud cells in chickens. In addition, we observed that T1R1 and T1R3 were co-expressed in about 5% of chickens' taste bud cells, which express T1R1 or T1R3. These results suggest that the heterodimer of T1R1 and T1R3 is rarely formed in chickens’ taste bud cells, and they provide comparative insights into the expressional regulation of taste receptors in the taste bud cells of vertebrates.
format	article
author	Yuta Yoshida Fuminori Kawabata Shotaro Nishimura Shoji Tabata
author_facet	Yuta Yoshida Fuminori Kawabata Shotaro Nishimura Shoji Tabata
author_sort	Yuta Yoshida
title	The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
title_short	The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
title_full	The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
title_fullStr	The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
title_full_unstemmed	The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
title_sort	umami receptor t1r1–t1r3 heterodimer is rarely formed in chickens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db98fdec813046ba9f48756d52d142f3
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The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens

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