Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway

The elucidation of amyloid nucleation mechanisms remains challenging as early oligomeric intermediates are transient and difficult to distinguish. Here the authors use Aβ- polyglutamine hybrid peptides designed to slow and limit amyloid maturation to provide insights into the structures of Aβ self-a...

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Autores principales:	Pinaki Misra, Ravindra Kodali, Saketh Chemuru, Karunakar Kar, Ronald Wetzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db9ce2df521e4e47a3b79fba5fc4d29d
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spelling	oai:doaj.org-article:db9ce2df521e4e47a3b79fba5fc4d29d2021-12-02T15:35:21ZRapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway10.1038/ncomms124192041-1723https://doaj.org/article/db9ce2df521e4e47a3b79fba5fc4d29d2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12419https://doaj.org/toc/2041-1723The elucidation of amyloid nucleation mechanisms remains challenging as early oligomeric intermediates are transient and difficult to distinguish. Here the authors use Aβ- polyglutamine hybrid peptides designed to slow and limit amyloid maturation to provide insights into the structures of Aβ self-assembly intermediates.Pinaki MisraRavindra KodaliSaketh ChemuruKarunakar KarRonald WetzelNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pinaki Misra Ravindra Kodali Saketh Chemuru Karunakar Kar Ronald Wetzel Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
description	The elucidation of amyloid nucleation mechanisms remains challenging as early oligomeric intermediates are transient and difficult to distinguish. Here the authors use Aβ- polyglutamine hybrid peptides designed to slow and limit amyloid maturation to provide insights into the structures of Aβ self-assembly intermediates.
format	article
author	Pinaki Misra Ravindra Kodali Saketh Chemuru Karunakar Kar Ronald Wetzel
author_facet	Pinaki Misra Ravindra Kodali Saketh Chemuru Karunakar Kar Ronald Wetzel
author_sort	Pinaki Misra
title	Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
title_short	Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
title_full	Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
title_fullStr	Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
title_full_unstemmed	Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
title_sort	rapid α-oligomer formation mediated by the aβ c terminus initiates an amyloid assembly pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/db9ce2df521e4e47a3b79fba5fc4d29d
work_keys_str_mv	AT pinakimisra rapidaoligomerformationmediatedbytheabcterminusinitiatesanamyloidassemblypathway AT ravindrakodali rapidaoligomerformationmediatedbytheabcterminusinitiatesanamyloidassemblypathway AT sakethchemuru rapidaoligomerformationmediatedbytheabcterminusinitiatesanamyloidassemblypathway AT karunakarkar rapidaoligomerformationmediatedbytheabcterminusinitiatesanamyloidassemblypathway AT ronaldwetzel rapidaoligomerformationmediatedbytheabcterminusinitiatesanamyloidassemblypathway
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Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway

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