Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway

The elucidation of amyloid nucleation mechanisms remains challenging as early oligomeric intermediates are transient and difficult to distinguish. Here the authors use Aβ- polyglutamine hybrid peptides designed to slow and limit amyloid maturation to provide insights into the structures of Aβ self-a...

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Autores principales: Pinaki Misra, Ravindra Kodali, Saketh Chemuru, Karunakar Kar, Ronald Wetzel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/db9ce2df521e4e47a3b79fba5fc4d29d
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