Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study

<h4>Background</h4> Myocardial perfusion imaging (MPI) is a well-established diagnostic tool to evaluate coronary artery disease (CAD) and also an effective prognostic tool for patients with CAD. However, few studies investigated the prognostic value of attenuation correction (AC) in MPI...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jei-Yie Huang, Ruoh-Fang Yen, Chun-Kai Huang, Chia-Ju Liu, Mei-Fang Cheng, Kuo-Liong Chien, Yen-Wen Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dba19c838ad14fb8802b73add1e950c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dba19c838ad14fb8802b73add1e950c0
record_format	dspace
spelling	oai:doaj.org-article:dba19c838ad14fb8802b73add1e950c02021-11-04T06:19:43ZLong-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study1932-6203https://doaj.org/article/dba19c838ad14fb8802b73add1e950c02021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547642/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Myocardial perfusion imaging (MPI) is a well-established diagnostic tool to evaluate coronary artery disease (CAD) and also an effective prognostic tool for patients with CAD. However, few studies investigated the prognostic value of attenuation correction (AC) in MPI, and the results were controversial. <h4>Objectives</h4> To investigate the prognostic value of computed tomography (CT)-based AC thallium-201 (Tl-201) MPI. <h4>Methods</h4> A total of 108 consecutive patients who underwent Tl-201 MPI and received coronary angiography within 90 days were included. Medical records were reviewed and missing information was completed after telephone contact. The prognostic value was evaluated by Kaplan-Meier analysis, univariable and multivariable Cox proportional hazards model. <h4>Results</h4> After a mean follow-up of 7.72 ± 3.72 years, 27 patients had died, 41 had been readmitted for cardiovascular (CV)-related events and 44 had reached the composite of death plus CV-related re-admission. Kaplan-Meier curves for all-cause mortality for SSS with a cutoff value of 13 for AC and 16 for non-AC (NAC) images showed a significant difference between the two curves for both AC and NAC images (p = 0.011 for AC and p = 0.021 for NAC). In the multivariable model, SSS and SRS showed similar independent predictive values in predicting all-cause mortality and composite of all-cause mortality plus CV-related re-admission, in both AC and NAC images. Subgroup analysis implicated that AC MPI possibly provided better risk stratification in obese patients. <h4>Conclusion</h4> CT-based AC and NAC MPI showed similar value and were the only significant predictors for the composite of mortality and CV events.Jei-Yie HuangRuoh-Fang YenChun-Kai HuangChia-Ju LiuMei-Fang ChengKuo-Liong ChienYen-Wen WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jei-Yie Huang Ruoh-Fang Yen Chun-Kai Huang Chia-Ju Liu Mei-Fang Cheng Kuo-Liong Chien Yen-Wen Wu Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study
description	<h4>Background</h4> Myocardial perfusion imaging (MPI) is a well-established diagnostic tool to evaluate coronary artery disease (CAD) and also an effective prognostic tool for patients with CAD. However, few studies investigated the prognostic value of attenuation correction (AC) in MPI, and the results were controversial. <h4>Objectives</h4> To investigate the prognostic value of computed tomography (CT)-based AC thallium-201 (Tl-201) MPI. <h4>Methods</h4> A total of 108 consecutive patients who underwent Tl-201 MPI and received coronary angiography within 90 days were included. Medical records were reviewed and missing information was completed after telephone contact. The prognostic value was evaluated by Kaplan-Meier analysis, univariable and multivariable Cox proportional hazards model. <h4>Results</h4> After a mean follow-up of 7.72 ± 3.72 years, 27 patients had died, 41 had been readmitted for cardiovascular (CV)-related events and 44 had reached the composite of death plus CV-related re-admission. Kaplan-Meier curves for all-cause mortality for SSS with a cutoff value of 13 for AC and 16 for non-AC (NAC) images showed a significant difference between the two curves for both AC and NAC images (p = 0.011 for AC and p = 0.021 for NAC). In the multivariable model, SSS and SRS showed similar independent predictive values in predicting all-cause mortality and composite of all-cause mortality plus CV-related re-admission, in both AC and NAC images. Subgroup analysis implicated that AC MPI possibly provided better risk stratification in obese patients. <h4>Conclusion</h4> CT-based AC and NAC MPI showed similar value and were the only significant predictors for the composite of mortality and CV events.
format	article
author	Jei-Yie Huang Ruoh-Fang Yen Chun-Kai Huang Chia-Ju Liu Mei-Fang Cheng Kuo-Liong Chien Yen-Wen Wu
author_facet	Jei-Yie Huang Ruoh-Fang Yen Chun-Kai Huang Chia-Ju Liu Mei-Fang Cheng Kuo-Liong Chien Yen-Wen Wu
author_sort	Jei-Yie Huang
title	Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study
title_short	Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study
title_full	Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study
title_fullStr	Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study
title_full_unstemmed	Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study
title_sort	long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: a cohort study
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dba19c838ad14fb8802b73add1e950c0
work_keys_str_mv	AT jeiyiehuang longtermprognosticvalueofcomputedtomographybasedattenuationcorrectiononthallium201myocardialperfusionimagingacohortstudy AT ruohfangyen longtermprognosticvalueofcomputedtomographybasedattenuationcorrectiononthallium201myocardialperfusionimagingacohortstudy AT chunkaihuang longtermprognosticvalueofcomputedtomographybasedattenuationcorrectiononthallium201myocardialperfusionimagingacohortstudy AT chiajuliu longtermprognosticvalueofcomputedtomographybasedattenuationcorrectiononthallium201myocardialperfusionimagingacohortstudy AT meifangcheng longtermprognosticvalueofcomputedtomographybasedattenuationcorrectiononthallium201myocardialperfusionimagingacohortstudy AT kuoliongchien longtermprognosticvalueofcomputedtomographybasedattenuationcorrectiononthallium201myocardialperfusionimagingacohortstudy AT yenwenwu longtermprognosticvalueofcomputedtomographybasedattenuationcorrectiononthallium201myocardialperfusionimagingacohortstudy
_version_	1718445120970293248

Long-term prognostic value of computed tomography-based attenuation correction on thallium-201 myocardial perfusion imaging: A cohort study

Ejemplares similares