Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast

Abstract Steroidal compounds are of great interest in the pharmaceutical field, with steroidal drugs as the second largest category of medicine in the world. Advances in synthetic biology and metabolic engineering have enabled de novo biosynthesis of sterols and steroids in yeast, which is a green a...

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Autores principales:	Yuehao Gu, Xue Jiao, Lidan Ye, Hongwei Yu
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Sterols and steroids De novo biosynthesis Yeast Metabolic engineering Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/dba4a53dfd57415fa9604740d4e524e9
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spelling	oai:doaj.org-article:dba4a53dfd57415fa9604740d4e524e92021-11-07T12:03:49ZMetabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast10.1186/s40643-021-00460-92197-4365https://doaj.org/article/dba4a53dfd57415fa9604740d4e524e92021-11-01T00:00:00Zhttps://doi.org/10.1186/s40643-021-00460-9https://doaj.org/toc/2197-4365Abstract Steroidal compounds are of great interest in the pharmaceutical field, with steroidal drugs as the second largest category of medicine in the world. Advances in synthetic biology and metabolic engineering have enabled de novo biosynthesis of sterols and steroids in yeast, which is a green and safe production route for these valuable steroidal compounds. In this review, we summarize the metabolic engineering strategies developed and employed for improving the de novo biosynthesis of sterols and steroids in yeast based on the regulation mechanisms, and introduce the recent progresses in de novo synthesis of some typical sterols and steroids in yeast. The remaining challenges and future perspectives are also discussed.Yuehao GuXue JiaoLidan YeHongwei YuSpringerOpenarticleSterols and steroidsDe novo biosynthesisYeastMetabolic engineeringTechnologyTChemical technologyTP1-1185BiotechnologyTP248.13-248.65ENBioresources and Bioprocessing, Vol 8, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sterols and steroids De novo biosynthesis Yeast Metabolic engineering Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65
spellingShingle	Sterols and steroids De novo biosynthesis Yeast Metabolic engineering Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65 Yuehao Gu Xue Jiao Lidan Ye Hongwei Yu Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast
description	Abstract Steroidal compounds are of great interest in the pharmaceutical field, with steroidal drugs as the second largest category of medicine in the world. Advances in synthetic biology and metabolic engineering have enabled de novo biosynthesis of sterols and steroids in yeast, which is a green and safe production route for these valuable steroidal compounds. In this review, we summarize the metabolic engineering strategies developed and employed for improving the de novo biosynthesis of sterols and steroids in yeast based on the regulation mechanisms, and introduce the recent progresses in de novo synthesis of some typical sterols and steroids in yeast. The remaining challenges and future perspectives are also discussed.
format	article
author	Yuehao Gu Xue Jiao Lidan Ye Hongwei Yu
author_facet	Yuehao Gu Xue Jiao Lidan Ye Hongwei Yu
author_sort	Yuehao Gu
title	Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast
title_short	Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast
title_full	Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast
title_fullStr	Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast
title_full_unstemmed	Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast
title_sort	metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/dba4a53dfd57415fa9604740d4e524e9
work_keys_str_mv	AT yuehaogu metabolicengineeringstrategiesfordenovobiosynthesisofsterolsandsteroidsinyeast AT xuejiao metabolicengineeringstrategiesfordenovobiosynthesisofsterolsandsteroidsinyeast AT lidanye metabolicengineeringstrategiesfordenovobiosynthesisofsterolsandsteroidsinyeast AT hongweiyu metabolicengineeringstrategiesfordenovobiosynthesisofsterolsandsteroidsinyeast
_version_	1718443580070035456

Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast

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