Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study

Abstract Patients with strong clinical features of COVID-19 with negative real time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing are not currently included in official statistics. The scale, characteristics and clinical relevance of this group are not well described. We performed a retrospe...

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Autores principales:	Paul Middleton, Pablo N. Perez-Guzman, Alexandra Cheng, Naveenta Kumar, Mara D. Kont, Anna Daunt, Sujit Mukherjee, Graham Cooke, Timothy B. Hallett, Katharina Hauck, Peter J. White, Mark R. Thursz, Shevanthi Nayagam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dba5f390c2b54ba39580e5f45381f9ad
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spelling	oai:doaj.org-article:dba5f390c2b54ba39580e5f45381f9ad2021-12-02T14:16:07ZCharacteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study10.1038/s41598-021-81930-02045-2322https://doaj.org/article/dba5f390c2b54ba39580e5f45381f9ad2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81930-0https://doaj.org/toc/2045-2322Abstract Patients with strong clinical features of COVID-19 with negative real time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing are not currently included in official statistics. The scale, characteristics and clinical relevance of this group are not well described. We performed a retrospective cohort study in two large London hospitals to characterize the demographic, clinical, and hospitalization outcome characteristics of swab-negative clinical COVID-19 patients. We found 1 in 5 patients with a negative swab and clinical suspicion of COVID-19 received a clinical diagnosis of COVID-19 within clinical documentation, discharge summary or death certificate. We compared this group to a similar swab positive cohort and found similar demographic composition, symptomology and laboratory findings. Swab-negative clinical COVID-19 patients had better outcomes, with shorter length of hospital stay, reduced need for > 60% supplementary oxygen and reduced mortality. Patients with strong clinical features of COVID-19 that are swab-negative are a common clinical challenge. Health systems must recognize and plan for the management of swab-negative patients in their COVID-19 clinical management, infection control policies and epidemiological assessments.Paul MiddletonPablo N. Perez-GuzmanAlexandra ChengNaveenta KumarMara D. KontAnna DauntSujit MukherjeeGraham CookeTimothy B. HallettKatharina HauckPeter J. WhiteMark R. ThurszShevanthi NayagamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paul Middleton Pablo N. Perez-Guzman Alexandra Cheng Naveenta Kumar Mara D. Kont Anna Daunt Sujit Mukherjee Graham Cooke Timothy B. Hallett Katharina Hauck Peter J. White Mark R. Thursz Shevanthi Nayagam Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study
description	Abstract Patients with strong clinical features of COVID-19 with negative real time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing are not currently included in official statistics. The scale, characteristics and clinical relevance of this group are not well described. We performed a retrospective cohort study in two large London hospitals to characterize the demographic, clinical, and hospitalization outcome characteristics of swab-negative clinical COVID-19 patients. We found 1 in 5 patients with a negative swab and clinical suspicion of COVID-19 received a clinical diagnosis of COVID-19 within clinical documentation, discharge summary or death certificate. We compared this group to a similar swab positive cohort and found similar demographic composition, symptomology and laboratory findings. Swab-negative clinical COVID-19 patients had better outcomes, with shorter length of hospital stay, reduced need for > 60% supplementary oxygen and reduced mortality. Patients with strong clinical features of COVID-19 that are swab-negative are a common clinical challenge. Health systems must recognize and plan for the management of swab-negative patients in their COVID-19 clinical management, infection control policies and epidemiological assessments.
format	article
author	Paul Middleton Pablo N. Perez-Guzman Alexandra Cheng Naveenta Kumar Mara D. Kont Anna Daunt Sujit Mukherjee Graham Cooke Timothy B. Hallett Katharina Hauck Peter J. White Mark R. Thursz Shevanthi Nayagam
author_facet	Paul Middleton Pablo N. Perez-Guzman Alexandra Cheng Naveenta Kumar Mara D. Kont Anna Daunt Sujit Mukherjee Graham Cooke Timothy B. Hallett Katharina Hauck Peter J. White Mark R. Thursz Shevanthi Nayagam
author_sort	Paul Middleton
title	Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study
title_short	Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study
title_full	Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study
title_fullStr	Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study
title_full_unstemmed	Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study
title_sort	characteristics and outcomes of clinically diagnosed rt-pcr swab negative covid-19: a retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dba5f390c2b54ba39580e5f45381f9ad
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Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study

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