MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease

Dorsal stream, which has a neuronal connection with dorsolateral prefrontal cortex (DLPFC), is known to be responsible for detection of motion including optic flow perception. Using magnetoencephalography (MEG), this study aimed to examine neural responses to optic flow stimuli with looming motion i...

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Autores principales:	Moeko Noguchi-Shinohara, Masato Koike, Hirofumi Morise, Kiwamu Kudo, Shoko Tsuchimine, Junji Komatsu, Chiemi Abe, Sachiko Kitagawa, Yoshihisa Ikeda, Masahito Yamada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dba78a8fd109422991e91cdef257d239
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spelling	oai:doaj.org-article:dba78a8fd109422991e91cdef257d2392021-11-11T07:51:49ZMEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease1932-6203https://doaj.org/article/dba78a8fd109422991e91cdef257d2392021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570504/?tool=EBIhttps://doaj.org/toc/1932-6203Dorsal stream, which has a neuronal connection with dorsolateral prefrontal cortex (DLPFC), is known to be responsible for detection of motion including optic flow perception. Using magnetoencephalography (MEG), this study aimed to examine neural responses to optic flow stimuli with looming motion in the DLPFC in patients with mild cognitive impairment due to Alzheimer’s disease (AD-MCI) compared with cognitively unimpaired participants (CU). We analyzed the neural responses by evaluating maximum source-localized power for the AD-MCI group (n = 11) and CU (n = 20), focusing on six regions of interest (ROIs) that form the DLPFC: right and left dorsal Brodmann area 9/46 (A9/46d), Brodmann area 46 (A46) and ventral Brodmann area 9/46 (A9/46v). We found significant differences in the maximum power between the groups in the left A46 and A9/46v. Moreover, in the left A9/46v, the maximum power significantly correlated with the Wechsler Memory Scale-Revised general memory score and delayed recall score. The maximum power in the left A9/46v also revealed high performance in AD-MCI versus CU classification with the area under the ROC curve of 0.90. This study demonstrated that MEG during the optic flow task can be useful in discriminating AD-MCI from CU.Moeko Noguchi-ShinoharaMasato KoikeHirofumi MoriseKiwamu KudoShoko TsuchimineJunji KomatsuChiemi AbeSachiko KitagawaYoshihisa IkedaMasahito YamadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moeko Noguchi-Shinohara Masato Koike Hirofumi Morise Kiwamu Kudo Shoko Tsuchimine Junji Komatsu Chiemi Abe Sachiko Kitagawa Yoshihisa Ikeda Masahito Yamada MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease
description	Dorsal stream, which has a neuronal connection with dorsolateral prefrontal cortex (DLPFC), is known to be responsible for detection of motion including optic flow perception. Using magnetoencephalography (MEG), this study aimed to examine neural responses to optic flow stimuli with looming motion in the DLPFC in patients with mild cognitive impairment due to Alzheimer’s disease (AD-MCI) compared with cognitively unimpaired participants (CU). We analyzed the neural responses by evaluating maximum source-localized power for the AD-MCI group (n = 11) and CU (n = 20), focusing on six regions of interest (ROIs) that form the DLPFC: right and left dorsal Brodmann area 9/46 (A9/46d), Brodmann area 46 (A46) and ventral Brodmann area 9/46 (A9/46v). We found significant differences in the maximum power between the groups in the left A46 and A9/46v. Moreover, in the left A9/46v, the maximum power significantly correlated with the Wechsler Memory Scale-Revised general memory score and delayed recall score. The maximum power in the left A9/46v also revealed high performance in AD-MCI versus CU classification with the area under the ROC curve of 0.90. This study demonstrated that MEG during the optic flow task can be useful in discriminating AD-MCI from CU.
format	article
author	Moeko Noguchi-Shinohara Masato Koike Hirofumi Morise Kiwamu Kudo Shoko Tsuchimine Junji Komatsu Chiemi Abe Sachiko Kitagawa Yoshihisa Ikeda Masahito Yamada
author_facet	Moeko Noguchi-Shinohara Masato Koike Hirofumi Morise Kiwamu Kudo Shoko Tsuchimine Junji Komatsu Chiemi Abe Sachiko Kitagawa Yoshihisa Ikeda Masahito Yamada
author_sort	Moeko Noguchi-Shinohara
title	MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease
title_short	MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease
title_full	MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease
title_fullStr	MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease
title_full_unstemmed	MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease
title_sort	meg activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to alzheimer’s disease
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dba78a8fd109422991e91cdef257d239
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MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease

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