Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels

Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joao Luis Carvalho-de-Souza, Andrea Saponaro, C. A. Z. Bassetto, Oliver Rauh, Indra Schroeder, Fabio Franciolini, Luigi Catacuzzeno, Francisco Bezanilla, Gerhard Thiel, Anna Moroni
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2022
Materias:	k+ channel gating voltage sensor selectivity filter intramolecular communication Physics QC1-999
Acceso en línea:	https://doaj.org/article/dbabf0c9c6e04b96afaf7dcc0631b561
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dbabf0c9c6e04b96afaf7dcc0631b561
record_format	dspace
spelling	oai:doaj.org-article:dbabf0c9c6e04b96afaf7dcc0631b5612021-11-04T15:51:57ZExperimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels2374-614910.1080/23746149.2021.1978317https://doaj.org/article/dbabf0c9c6e04b96afaf7dcc0631b5612022-01-01T00:00:00Zhttp://dx.doi.org/10.1080/23746149.2021.1978317https://doaj.org/toc/2374-6149Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid-state nanopores as sensors or switches for practical applications. Here, we summarize recent advancements in understanding the mechanisms of ion permeation and gating in channel proteins with a focus on the elementary steps of ion transport through the pore and on non-canonical modes of intramolecular communication between peripheral sensory domains and the central channel pore.Joao Luis Carvalho-de-SouzaAndrea SaponaroC. A. Z. BassettoOliver RauhIndra SchroederFabio FrancioliniLuigi CatacuzzenoFrancisco BezanillaGerhard ThielAnna MoroniTaylor & Francis Grouparticlek+ channelgatingvoltage sensorselectivity filterintramolecular communicationPhysicsQC1-999ENAdvances in Physics: X, Vol 7, Iss 1 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	k+ channel gating voltage sensor selectivity filter intramolecular communication Physics QC1-999
spellingShingle	k+ channel gating voltage sensor selectivity filter intramolecular communication Physics QC1-999 Joao Luis Carvalho-de-Souza Andrea Saponaro C. A. Z. Bassetto Oliver Rauh Indra Schroeder Fabio Franciolini Luigi Catacuzzeno Francisco Bezanilla Gerhard Thiel Anna Moroni Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
description	Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid-state nanopores as sensors or switches for practical applications. Here, we summarize recent advancements in understanding the mechanisms of ion permeation and gating in channel proteins with a focus on the elementary steps of ion transport through the pore and on non-canonical modes of intramolecular communication between peripheral sensory domains and the central channel pore.
format	article
author	Joao Luis Carvalho-de-Souza Andrea Saponaro C. A. Z. Bassetto Oliver Rauh Indra Schroeder Fabio Franciolini Luigi Catacuzzeno Francisco Bezanilla Gerhard Thiel Anna Moroni
author_facet	Joao Luis Carvalho-de-Souza Andrea Saponaro C. A. Z. Bassetto Oliver Rauh Indra Schroeder Fabio Franciolini Luigi Catacuzzeno Francisco Bezanilla Gerhard Thiel Anna Moroni
author_sort	Joao Luis Carvalho-de-Souza
title	Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
title_short	Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
title_full	Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
title_fullStr	Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
title_full_unstemmed	Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
title_sort	experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
publisher	Taylor & Francis Group
publishDate	2022
url	https://doaj.org/article/dbabf0c9c6e04b96afaf7dcc0631b561
work_keys_str_mv	AT joaoluiscarvalhodesouza experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT andreasaponaro experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT cazbassetto experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT oliverrauh experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT indraschroeder experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT fabiofranciolini experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT luigicatacuzzeno experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT franciscobezanilla experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT gerhardthiel experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels AT annamoroni experimentalchallengesinionchannelresearchuncoveringbasicprinciplesofpermeationandgatinginpotassiumchannels
_version_	1718444681560326144

Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels

Ejemplares similares