Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury

Mitochondria are the central target of ischemic preconditioning and postconditioning cardioprotective strategies, which consist of either the application of brief intermittent ischemia/reperfusion (I/R) cycles or the administration of pharmacological agents. Such strategies reduce cardiac I/R injury...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wylly Ramsés García-Niño, Cecilia Zazueta, Mabel Buelna-Chontal, Alejandro Silva-Palacios
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	myocardial infarction ischemic preconditioning ischemic postconditioning cardioprotection mitochondrial biogenesis mitochondrial dynamics Science Q
Acceso en línea:	https://doaj.org/article/dbb21420bd6d4696aa2fe7b1a70bb9fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dbb21420bd6d4696aa2fe7b1a70bb9fe
record_format	dspace
spelling	oai:doaj.org-article:dbb21420bd6d4696aa2fe7b1a70bb9fe2021-11-25T18:10:27ZMitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury10.3390/life111111232075-1729https://doaj.org/article/dbb21420bd6d4696aa2fe7b1a70bb9fe2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1123https://doaj.org/toc/2075-1729Mitochondria are the central target of ischemic preconditioning and postconditioning cardioprotective strategies, which consist of either the application of brief intermittent ischemia/reperfusion (I/R) cycles or the administration of pharmacological agents. Such strategies reduce cardiac I/R injury by activating protective signaling pathways that prevent the exacerbated production of reactive oxygen/nitrogen species, inhibit opening of mitochondrial permeability transition pore and reduce apoptosis, maintaining normal mitochondrial function. Cardioprotection also involves the activation of mitochondrial quality control (MQC) processes, which replace defective mitochondria or eliminate mitochondrial debris, preserving the structure and function of the network of these organelles, and consequently ensuring homeostasis and survival of cardiomyocytes. Such processes include mitochondrial biogenesis, fission, fusion, mitophagy and mitochondrial-controlled cell death. This review updates recent advances in MQC mechanisms that are activated in the protection conferred by different cardiac conditioning interventions. Furthermore, the role of extracellular vesicles in mitochondrial protection and turnover of these organelles will be discussed. It is concluded that modulation of MQC mechanisms and recognition of mitochondrial targets could provide a potential and selective therapeutic approach for I/R-induced mitochondrial dysfunction.Wylly Ramsés García-NiñoCecilia ZazuetaMabel Buelna-ChontalAlejandro Silva-PalaciosMDPI AGarticlemyocardial infarctionischemic preconditioningischemic postconditioningcardioprotectionmitochondrial biogenesismitochondrial dynamicsScienceQENLife, Vol 11, Iss 1123, p 1123 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	myocardial infarction ischemic preconditioning ischemic postconditioning cardioprotection mitochondrial biogenesis mitochondrial dynamics Science Q
spellingShingle	myocardial infarction ischemic preconditioning ischemic postconditioning cardioprotection mitochondrial biogenesis mitochondrial dynamics Science Q Wylly Ramsés García-Niño Cecilia Zazueta Mabel Buelna-Chontal Alejandro Silva-Palacios Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury
description	Mitochondria are the central target of ischemic preconditioning and postconditioning cardioprotective strategies, which consist of either the application of brief intermittent ischemia/reperfusion (I/R) cycles or the administration of pharmacological agents. Such strategies reduce cardiac I/R injury by activating protective signaling pathways that prevent the exacerbated production of reactive oxygen/nitrogen species, inhibit opening of mitochondrial permeability transition pore and reduce apoptosis, maintaining normal mitochondrial function. Cardioprotection also involves the activation of mitochondrial quality control (MQC) processes, which replace defective mitochondria or eliminate mitochondrial debris, preserving the structure and function of the network of these organelles, and consequently ensuring homeostasis and survival of cardiomyocytes. Such processes include mitochondrial biogenesis, fission, fusion, mitophagy and mitochondrial-controlled cell death. This review updates recent advances in MQC mechanisms that are activated in the protection conferred by different cardiac conditioning interventions. Furthermore, the role of extracellular vesicles in mitochondrial protection and turnover of these organelles will be discussed. It is concluded that modulation of MQC mechanisms and recognition of mitochondrial targets could provide a potential and selective therapeutic approach for I/R-induced mitochondrial dysfunction.
format	article
author	Wylly Ramsés García-Niño Cecilia Zazueta Mabel Buelna-Chontal Alejandro Silva-Palacios
author_facet	Wylly Ramsés García-Niño Cecilia Zazueta Mabel Buelna-Chontal Alejandro Silva-Palacios
author_sort	Wylly Ramsés García-Niño
title	Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury
title_short	Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury
title_full	Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury
title_fullStr	Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury
title_full_unstemmed	Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury
title_sort	mitochondrial quality control in cardiac-conditioning strategies against ischemia-reperfusion injury
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dbb21420bd6d4696aa2fe7b1a70bb9fe
work_keys_str_mv	AT wyllyramsesgarcianino mitochondrialqualitycontrolincardiacconditioningstrategiesagainstischemiareperfusioninjury AT ceciliazazueta mitochondrialqualitycontrolincardiacconditioningstrategiesagainstischemiareperfusioninjury AT mabelbuelnachontal mitochondrialqualitycontrolincardiacconditioningstrategiesagainstischemiareperfusioninjury AT alejandrosilvapalacios mitochondrialqualitycontrolincardiacconditioningstrategiesagainstischemiareperfusioninjury
_version_	1718411529227862016

Mitochondrial Quality Control in Cardiac-Conditioning Strategies against Ischemia-Reperfusion Injury

Ejemplares similares