Muscular effects of statins in the elderly female: a review

Shilpa Bhardwaj,1,2 Shalini Selvarajah,3 Eric B Schneider31Griffin Hospital, Derby, CT, USA; 2Yale University, New Haven, CT, USA; 3Center for Surgical Trials and Outcomes Research, Johns Hopkins School of Medicine, Baltimore, MD, USAAbstract: Statins have demonstrated substantial benefits in suppor...

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Autores principales:	Bhardwaj S, Selvarajah S, Schneider EB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Statins Older Adults Elderly Females Epidemiology Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/dbb5c95c69be42adb75558243578232f
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spelling	oai:doaj.org-article:dbb5c95c69be42adb75558243578232f2021-12-02T07:27:15ZMuscular effects of statins in the elderly female: a review1178-1998https://doaj.org/article/dbb5c95c69be42adb75558243578232f2013-01-01T00:00:00Zhttps://www.dovepress.com/muscular-effects-of-statins-in-the-elderly-female-a-review-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Shilpa Bhardwaj,1,2 Shalini Selvarajah,3 Eric B Schneider31Griffin Hospital, Derby, CT, USA; 2Yale University, New Haven, CT, USA; 3Center for Surgical Trials and Outcomes Research, Johns Hopkins School of Medicine, Baltimore, MD, USAAbstract: Statins have demonstrated substantial benefits in supporting cardiovascular health. Older individuals are more likely to experience the well-known muscle-related side effects of statins compared with younger individuals. Elderly females may be especially vulnerable to statin-related muscle disorder. This review will collate and discuss statin-related muscular effects, examine their molecular and genetic basis, and how these apply specifically to elderly women. Developing strategies to reduce the incidence of statin-induced myopathy in older adult women could contribute to a significant reduction in the overall incidence of statin-induced muscle disorder in this vulnerable group of patients. Reducing statin-related muscle disorder would likely improve overall patient compliance, thereby leading to an increase in improved short- and long-term outcomes associated with appropriate use of statins.Keywords: statins, older adults, elderly, females, epidemiologyBhardwaj SSelvarajah SSchneider EBDove Medical PressarticleStatinsOlder AdultsElderlyFemalesEpidemiologyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 47-59 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Statins Older Adults Elderly Females Epidemiology Geriatrics RC952-954.6
spellingShingle	Statins Older Adults Elderly Females Epidemiology Geriatrics RC952-954.6 Bhardwaj S Selvarajah S Schneider EB Muscular effects of statins in the elderly female: a review
description	Shilpa Bhardwaj,1,2 Shalini Selvarajah,3 Eric B Schneider31Griffin Hospital, Derby, CT, USA; 2Yale University, New Haven, CT, USA; 3Center for Surgical Trials and Outcomes Research, Johns Hopkins School of Medicine, Baltimore, MD, USAAbstract: Statins have demonstrated substantial benefits in supporting cardiovascular health. Older individuals are more likely to experience the well-known muscle-related side effects of statins compared with younger individuals. Elderly females may be especially vulnerable to statin-related muscle disorder. This review will collate and discuss statin-related muscular effects, examine their molecular and genetic basis, and how these apply specifically to elderly women. Developing strategies to reduce the incidence of statin-induced myopathy in older adult women could contribute to a significant reduction in the overall incidence of statin-induced muscle disorder in this vulnerable group of patients. Reducing statin-related muscle disorder would likely improve overall patient compliance, thereby leading to an increase in improved short- and long-term outcomes associated with appropriate use of statins.Keywords: statins, older adults, elderly, females, epidemiology
format	article
author	Bhardwaj S Selvarajah S Schneider EB
author_facet	Bhardwaj S Selvarajah S Schneider EB
author_sort	Bhardwaj S
title	Muscular effects of statins in the elderly female: a review
title_short	Muscular effects of statins in the elderly female: a review
title_full	Muscular effects of statins in the elderly female: a review
title_fullStr	Muscular effects of statins in the elderly female: a review
title_full_unstemmed	Muscular effects of statins in the elderly female: a review
title_sort	muscular effects of statins in the elderly female: a review
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/dbb5c95c69be42adb75558243578232f
work_keys_str_mv	AT bhardwajs musculareffectsofstatinsintheelderlyfemaleareview AT selvarajahs musculareffectsofstatinsintheelderlyfemaleareview AT schneidereb musculareffectsofstatinsintheelderlyfemaleareview
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Muscular effects of statins in the elderly female: a review

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