EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

EGFR is frequently constitutively active in glioblastoma (GBM). Here, the authors show that EGFR induces YTHDF2 protein stabilization, which reduces cholesterol homeostasis through an RNA m6A methylation dependent molecular mechanism to promote GBM tumourigenesis.

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Autores principales: Runping Fang, Xin Chen, Sicong Zhang, Hui Shi, Youqiong Ye, Hailing Shi, Zhongyu Zou, Peng Li, Qing Guo, Li Ma, Chuan He, Suyun Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/dbb72d0750a2491f8e7c06b1a87b4c5f
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spelling oai:doaj.org-article:dbb72d0750a2491f8e7c06b1a87b4c5f2021-12-02T15:07:19ZEGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma10.1038/s41467-020-20379-72041-1723https://doaj.org/article/dbb72d0750a2491f8e7c06b1a87b4c5f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20379-7https://doaj.org/toc/2041-1723EGFR is frequently constitutively active in glioblastoma (GBM). Here, the authors show that EGFR induces YTHDF2 protein stabilization, which reduces cholesterol homeostasis through an RNA m6A methylation dependent molecular mechanism to promote GBM tumourigenesis.Runping FangXin ChenSicong ZhangHui ShiYouqiong YeHailing ShiZhongyu ZouPeng LiQing GuoLi MaChuan HeSuyun HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Runping Fang
Xin Chen
Sicong Zhang
Hui Shi
Youqiong Ye
Hailing Shi
Zhongyu Zou
Peng Li
Qing Guo
Li Ma
Chuan He
Suyun Huang
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
description EGFR is frequently constitutively active in glioblastoma (GBM). Here, the authors show that EGFR induces YTHDF2 protein stabilization, which reduces cholesterol homeostasis through an RNA m6A methylation dependent molecular mechanism to promote GBM tumourigenesis.
format article
author Runping Fang
Xin Chen
Sicong Zhang
Hui Shi
Youqiong Ye
Hailing Shi
Zhongyu Zou
Peng Li
Qing Guo
Li Ma
Chuan He
Suyun Huang
author_facet Runping Fang
Xin Chen
Sicong Zhang
Hui Shi
Youqiong Ye
Hailing Shi
Zhongyu Zou
Peng Li
Qing Guo
Li Ma
Chuan He
Suyun Huang
author_sort Runping Fang
title EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_short EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_full EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_fullStr EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_full_unstemmed EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_sort egfr/src/erk-stabilized ythdf2 promotes cholesterol dysregulation and invasive growth of glioblastoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/dbb72d0750a2491f8e7c06b1a87b4c5f
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