EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

EGFR is frequently constitutively active in glioblastoma (GBM). Here, the authors show that EGFR induces YTHDF2 protein stabilization, which reduces cholesterol homeostasis through an RNA m6A methylation dependent molecular mechanism to promote GBM tumourigenesis.

Saved in:

Bibliographic Details
Main Authors:	Runping Fang, Xin Chen, Sicong Zhang, Hui Shi, Youqiong Ye, Hailing Shi, Zhongyu Zou, Peng Li, Qing Guo, Li Ma, Chuan He, Suyun Huang
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/dbb72d0750a2491f8e7c06b1a87b4c5f
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:dbb72d0750a2491f8e7c06b1a87b4c5f
record_format	dspace
spelling	oai:doaj.org-article:dbb72d0750a2491f8e7c06b1a87b4c5f2021-12-02T15:07:19ZEGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma10.1038/s41467-020-20379-72041-1723https://doaj.org/article/dbb72d0750a2491f8e7c06b1a87b4c5f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20379-7https://doaj.org/toc/2041-1723EGFR is frequently constitutively active in glioblastoma (GBM). Here, the authors show that EGFR induces YTHDF2 protein stabilization, which reduces cholesterol homeostasis through an RNA m6A methylation dependent molecular mechanism to promote GBM tumourigenesis.Runping FangXin ChenSicong ZhangHui ShiYouqiong YeHailing ShiZhongyu ZouPeng LiQing GuoLi MaChuan HeSuyun HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Runping Fang Xin Chen Sicong Zhang Hui Shi Youqiong Ye Hailing Shi Zhongyu Zou Peng Li Qing Guo Li Ma Chuan He Suyun Huang EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
description	EGFR is frequently constitutively active in glioblastoma (GBM). Here, the authors show that EGFR induces YTHDF2 protein stabilization, which reduces cholesterol homeostasis through an RNA m6A methylation dependent molecular mechanism to promote GBM tumourigenesis.
format	article
author	Runping Fang Xin Chen Sicong Zhang Hui Shi Youqiong Ye Hailing Shi Zhongyu Zou Peng Li Qing Guo Li Ma Chuan He Suyun Huang
author_facet	Runping Fang Xin Chen Sicong Zhang Hui Shi Youqiong Ye Hailing Shi Zhongyu Zou Peng Li Qing Guo Li Ma Chuan He Suyun Huang
author_sort	Runping Fang
title	EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_short	EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_full	EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_fullStr	EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_full_unstemmed	EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
title_sort	egfr/src/erk-stabilized ythdf2 promotes cholesterol dysregulation and invasive growth of glioblastoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dbb72d0750a2491f8e7c06b1a87b4c5f
work_keys_str_mv	AT runpingfang egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT xinchen egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT sicongzhang egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT huishi egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT youqiongye egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT hailingshi egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT zhongyuzou egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT pengli egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT qingguo egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT lima egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT chuanhe egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma AT suyunhuang egfrsrcerkstabilizedythdf2promotescholesteroldysregulationandinvasivegrowthofglioblastoma
_version_	1718388482319056896

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

Similar Items