ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes
HRD1 is an E3 ligase known to play a role in targeting degradation of misfolded proteins in the ER. Here the authors show that HRD1 interacts with metabolic enzymes and its liver specific deficiency results in lower body weight, blood glucose and plasma lipids during high fat diet in mice.
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/dbba9017edc14c20b4a2be08a43dd76f |
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oai:doaj.org-article:dbba9017edc14c20b4a2be08a43dd76f2021-12-02T16:56:56ZER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes10.1038/s41467-018-06091-72041-1723https://doaj.org/article/dbba9017edc14c20b4a2be08a43dd76f2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06091-7https://doaj.org/toc/2041-1723HRD1 is an E3 ligase known to play a role in targeting degradation of misfolded proteins in the ER. Here the authors show that HRD1 interacts with metabolic enzymes and its liver specific deficiency results in lower body weight, blood glucose and plasma lipids during high fat diet in mice.Juncheng WeiYanzhi YuanLu ChenYuanming XuYuehui ZhangYajun WangYanjie YangClara Bien PeekLauren DieboldYi YangBeixue GaoChaozhi JinJohanna Melo-CardenasNavdeep S. ChandelDonna D. ZhangHui PanKezhong ZhangJian WangFuchu HeDeyu FangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Juncheng Wei Yanzhi Yuan Lu Chen Yuanming Xu Yuehui Zhang Yajun Wang Yanjie Yang Clara Bien Peek Lauren Diebold Yi Yang Beixue Gao Chaozhi Jin Johanna Melo-Cardenas Navdeep S. Chandel Donna D. Zhang Hui Pan Kezhong Zhang Jian Wang Fuchu He Deyu Fang ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes |
| description |
HRD1 is an E3 ligase known to play a role in targeting degradation of misfolded proteins in the ER. Here the authors show that HRD1 interacts with metabolic enzymes and its liver specific deficiency results in lower body weight, blood glucose and plasma lipids during high fat diet in mice. |
| format |
article |
| author |
Juncheng Wei Yanzhi Yuan Lu Chen Yuanming Xu Yuehui Zhang Yajun Wang Yanjie Yang Clara Bien Peek Lauren Diebold Yi Yang Beixue Gao Chaozhi Jin Johanna Melo-Cardenas Navdeep S. Chandel Donna D. Zhang Hui Pan Kezhong Zhang Jian Wang Fuchu He Deyu Fang |
| author_facet |
Juncheng Wei Yanzhi Yuan Lu Chen Yuanming Xu Yuehui Zhang Yajun Wang Yanjie Yang Clara Bien Peek Lauren Diebold Yi Yang Beixue Gao Chaozhi Jin Johanna Melo-Cardenas Navdeep S. Chandel Donna D. Zhang Hui Pan Kezhong Zhang Jian Wang Fuchu He Deyu Fang |
| author_sort |
Juncheng Wei |
| title |
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes |
| title_short |
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes |
| title_full |
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes |
| title_fullStr |
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes |
| title_full_unstemmed |
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes |
| title_sort |
er-associated ubiquitin ligase hrd1 programs liver metabolism by targeting multiple metabolic enzymes |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/dbba9017edc14c20b4a2be08a43dd76f |
| work_keys_str_mv |
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