Practical aspects of the application of helical tomotherapy for craniospinal irradiation

Abstract We investigated the practical aspects of the application of craniospinal irradiation using helical tomotherapy (HT-CSI) by evaluating interfractional setup errors and intrafractional movement during each treatment in 83 patients undergoing HT-CSI between January 2014 and December 2018. Inte...

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Autores principales:	Joongyo Lee, Euidam Kim, Nalee Kim, Hwa Kyung Byun, Chang-Ok Suh, Yoonsun Chung, Hong In Yoon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dbbb68aad7c34fe281b230aa30d82157
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spelling	oai:doaj.org-article:dbbb68aad7c34fe281b230aa30d821572021-12-02T11:39:47ZPractical aspects of the application of helical tomotherapy for craniospinal irradiation10.1038/s41598-021-85574-y2045-2322https://doaj.org/article/dbbb68aad7c34fe281b230aa30d821572021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85574-yhttps://doaj.org/toc/2045-2322Abstract We investigated the practical aspects of the application of craniospinal irradiation using helical tomotherapy (HT-CSI) by evaluating interfractional setup errors and intrafractional movement during each treatment in 83 patients undergoing HT-CSI between January 2014 and December 2018. Interfractional setup errors in each axis (mediolateral; ML, craniocaudal; CC, and anteroposterior; AP) were assessed as differences between pre-treatment megavoltage computed tomography (MVCT) images scanned (zygomatic arch to the C4 spine) and planning CT images. Intrafractional movements were evaluated as the difference between pre-treatment and post-treatment MVCT (T12–L4 spine) images at each fraction. Median interfractional setup error was acceptable in every axis (ML: 1.6 mm, CC: 1.9 mm, AP: 3.1 mm). Seven patients (8.4%) experienced significant intrafractional displacement from 1 to 10 fractions (0.34% for ML, 0.74% for CC, 1.21% for AP). Weight loss grade 1+ during treatment (p = 0.016) was an independent risk factor for significant intrafractional displacement. The risk factor for significant intrafractional movement in pediatric patients was weight loss grade 1+ (p = 0.020), while there was no factor in adults. HT-CSI could be a feasible treatment modality with acceptable setup verification. Inter- and intrafractional errors were acceptable; paying attention to weight loss during treatment is necessary, especially in pediatric patients.Joongyo LeeEuidam KimNalee KimHwa Kyung ByunChang-Ok SuhYoonsun ChungHong In YoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joongyo Lee Euidam Kim Nalee Kim Hwa Kyung Byun Chang-Ok Suh Yoonsun Chung Hong In Yoon Practical aspects of the application of helical tomotherapy for craniospinal irradiation
description	Abstract We investigated the practical aspects of the application of craniospinal irradiation using helical tomotherapy (HT-CSI) by evaluating interfractional setup errors and intrafractional movement during each treatment in 83 patients undergoing HT-CSI between January 2014 and December 2018. Interfractional setup errors in each axis (mediolateral; ML, craniocaudal; CC, and anteroposterior; AP) were assessed as differences between pre-treatment megavoltage computed tomography (MVCT) images scanned (zygomatic arch to the C4 spine) and planning CT images. Intrafractional movements were evaluated as the difference between pre-treatment and post-treatment MVCT (T12–L4 spine) images at each fraction. Median interfractional setup error was acceptable in every axis (ML: 1.6 mm, CC: 1.9 mm, AP: 3.1 mm). Seven patients (8.4%) experienced significant intrafractional displacement from 1 to 10 fractions (0.34% for ML, 0.74% for CC, 1.21% for AP). Weight loss grade 1+ during treatment (p = 0.016) was an independent risk factor for significant intrafractional displacement. The risk factor for significant intrafractional movement in pediatric patients was weight loss grade 1+ (p = 0.020), while there was no factor in adults. HT-CSI could be a feasible treatment modality with acceptable setup verification. Inter- and intrafractional errors were acceptable; paying attention to weight loss during treatment is necessary, especially in pediatric patients.
format	article
author	Joongyo Lee Euidam Kim Nalee Kim Hwa Kyung Byun Chang-Ok Suh Yoonsun Chung Hong In Yoon
author_facet	Joongyo Lee Euidam Kim Nalee Kim Hwa Kyung Byun Chang-Ok Suh Yoonsun Chung Hong In Yoon
author_sort	Joongyo Lee
title	Practical aspects of the application of helical tomotherapy for craniospinal irradiation
title_short	Practical aspects of the application of helical tomotherapy for craniospinal irradiation
title_full	Practical aspects of the application of helical tomotherapy for craniospinal irradiation
title_fullStr	Practical aspects of the application of helical tomotherapy for craniospinal irradiation
title_full_unstemmed	Practical aspects of the application of helical tomotherapy for craniospinal irradiation
title_sort	practical aspects of the application of helical tomotherapy for craniospinal irradiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dbbb68aad7c34fe281b230aa30d82157
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Practical aspects of the application of helical tomotherapy for craniospinal irradiation

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