Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation

The microtubule binding protein TPX2 enhances branching microtubule nucleation though the current mechanisms are unclear. Here, the authors show that TPX2 undergoes liquid-liquid phase separation and co-condensates with tubulin to enhance TPX2-mediated microtubule nucleation.

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Autores principales:	Matthew R. King, Sabine Petry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dbc419461bb748b59e1b2901fdbf6acc
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spelling	oai:doaj.org-article:dbc419461bb748b59e1b2901fdbf6acc2021-12-02T17:31:41ZPhase separation of TPX2 enhances and spatially coordinates microtubule nucleation10.1038/s41467-019-14087-02041-1723https://doaj.org/article/dbc419461bb748b59e1b2901fdbf6acc2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14087-0https://doaj.org/toc/2041-1723The microtubule binding protein TPX2 enhances branching microtubule nucleation though the current mechanisms are unclear. Here, the authors show that TPX2 undergoes liquid-liquid phase separation and co-condensates with tubulin to enhance TPX2-mediated microtubule nucleation.Matthew R. KingSabine PetryNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew R. King Sabine Petry Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
description	The microtubule binding protein TPX2 enhances branching microtubule nucleation though the current mechanisms are unclear. Here, the authors show that TPX2 undergoes liquid-liquid phase separation and co-condensates with tubulin to enhance TPX2-mediated microtubule nucleation.
format	article
author	Matthew R. King Sabine Petry
author_facet	Matthew R. King Sabine Petry
author_sort	Matthew R. King
title	Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
title_short	Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
title_full	Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
title_fullStr	Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
title_full_unstemmed	Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
title_sort	phase separation of tpx2 enhances and spatially coordinates microtubule nucleation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dbc419461bb748b59e1b2901fdbf6acc
work_keys_str_mv	AT matthewrking phaseseparationoftpx2enhancesandspatiallycoordinatesmicrotubulenucleation AT sabinepetry phaseseparationoftpx2enhancesandspatiallycoordinatesmicrotubulenucleation
_version_	1718380584418410496

Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation

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