Development of a standardized MRI protocol for pancreas assessment in humans.
Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas imaging into multisite trials. The purpose of this st...
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2021
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oai:doaj.org-article:dbc9dc62256a40189372bb1641b4d5fe2021-12-02T20:17:38ZDevelopment of a standardized MRI protocol for pancreas assessment in humans.1932-620310.1371/journal.pone.0256029https://doaj.org/article/dbc9dc62256a40189372bb1641b4d5fe2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256029https://doaj.org/toc/1932-6203Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas imaging into multisite trials. The purpose of this study was to develop a standardized MRI protocol for pancreas imaging and to define the reproducibility of these measurements. Calibrated phantoms with known MRI properties were imaged at five sites with differing MRI hardware and software to develop a harmonized MRI imaging protocol. Subsequently, five healthy volunteers underwent MRI at four sites using the harmonized protocol to assess pancreas size, shape, apparent diffusion coefficient (ADC), longitudinal relaxation time (T1), magnetization transfer ratio (MTR), and pancreas and hepatic fat fraction. Following harmonization, pancreas size, surface area to volume ratio, diffusion, and longitudinal relaxation time were reproducible, with coefficients of variation less than 10%. In contrast, non-standardized image processing led to greater variation in MRI measurements. By using a standardized MRI image acquisition and processing protocol, quantitative MRI of the pancreas performed at multiple locations can be incorporated into clinical trials comparing pancreas imaging measures and metabolic state in individuals with type 1 or type 2 diabetes.John VirostkoRichard C CraddockJonathan M WilliamsTaylor M TrioloMelissa A HilmesHakmook KangLiping DuJordan J WrightMara KinneyJeffrey H MakiMilica MedvedMichaela WaibelThomas W H KayHelen E ThomasSiri Atma W GreeleyAndrea K SteckDaniel J MooreAlvin C PowersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256029 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q John Virostko Richard C Craddock Jonathan M Williams Taylor M Triolo Melissa A Hilmes Hakmook Kang Liping Du Jordan J Wright Mara Kinney Jeffrey H Maki Milica Medved Michaela Waibel Thomas W H Kay Helen E Thomas Siri Atma W Greeley Andrea K Steck Daniel J Moore Alvin C Powers Development of a standardized MRI protocol for pancreas assessment in humans. |
| description |
Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas imaging into multisite trials. The purpose of this study was to develop a standardized MRI protocol for pancreas imaging and to define the reproducibility of these measurements. Calibrated phantoms with known MRI properties were imaged at five sites with differing MRI hardware and software to develop a harmonized MRI imaging protocol. Subsequently, five healthy volunteers underwent MRI at four sites using the harmonized protocol to assess pancreas size, shape, apparent diffusion coefficient (ADC), longitudinal relaxation time (T1), magnetization transfer ratio (MTR), and pancreas and hepatic fat fraction. Following harmonization, pancreas size, surface area to volume ratio, diffusion, and longitudinal relaxation time were reproducible, with coefficients of variation less than 10%. In contrast, non-standardized image processing led to greater variation in MRI measurements. By using a standardized MRI image acquisition and processing protocol, quantitative MRI of the pancreas performed at multiple locations can be incorporated into clinical trials comparing pancreas imaging measures and metabolic state in individuals with type 1 or type 2 diabetes. |
| format |
article |
| author |
John Virostko Richard C Craddock Jonathan M Williams Taylor M Triolo Melissa A Hilmes Hakmook Kang Liping Du Jordan J Wright Mara Kinney Jeffrey H Maki Milica Medved Michaela Waibel Thomas W H Kay Helen E Thomas Siri Atma W Greeley Andrea K Steck Daniel J Moore Alvin C Powers |
| author_facet |
John Virostko Richard C Craddock Jonathan M Williams Taylor M Triolo Melissa A Hilmes Hakmook Kang Liping Du Jordan J Wright Mara Kinney Jeffrey H Maki Milica Medved Michaela Waibel Thomas W H Kay Helen E Thomas Siri Atma W Greeley Andrea K Steck Daniel J Moore Alvin C Powers |
| author_sort |
John Virostko |
| title |
Development of a standardized MRI protocol for pancreas assessment in humans. |
| title_short |
Development of a standardized MRI protocol for pancreas assessment in humans. |
| title_full |
Development of a standardized MRI protocol for pancreas assessment in humans. |
| title_fullStr |
Development of a standardized MRI protocol for pancreas assessment in humans. |
| title_full_unstemmed |
Development of a standardized MRI protocol for pancreas assessment in humans. |
| title_sort |
development of a standardized mri protocol for pancreas assessment in humans. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/dbc9dc62256a40189372bb1641b4d5fe |
| work_keys_str_mv |
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1718374377202909184 |