COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions

ABSTRACT Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and first emerged in December 2019 in Wuhan, Hubei province, China. Since then, the virus has rapidly spread to many countries. While the outbreak in China app...

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Autores principales:	Chris R. Triggle, Devendra Bansal, Elmoubasher Abu Baker Abd Farag, Hong Ding, Ali A. Sultan
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	COVID-19 drugs vaccines Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/dbcf19db4b11485ebbc71d035b98666c
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spelling	oai:doaj.org-article:dbcf19db4b11485ebbc71d035b98666c2021-11-15T15:30:16ZCOVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions10.1128/mSphere.00317-202379-5042https://doaj.org/article/dbcf19db4b11485ebbc71d035b98666c2020-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00317-20https://doaj.org/toc/2379-5042ABSTRACT Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and first emerged in December 2019 in Wuhan, Hubei province, China. Since then, the virus has rapidly spread to many countries. While the outbreak in China appears to be in decline, the disease has spread across the world, with a daily increase in the number of confirmed cases and infection-related deaths. Here, we highlight (i) the lessons that have been learnt so far and how they will benefit reducing the impact of COVID-19 disease and (ii) an update on the status of drug treatment and vaccine development to prevent COVID-19 and potential future related pandemics. Although the mortality rate is clearly higher than for influenza, the rate does seem to vary from country to country, possibly reflecting differences in how rapidly local health authorities respond to isolate and effectively care for the affected population. Drugs are urgently needed for both prophylaxis and the treatment of severely ill patients; however, no proven effective therapies for SARS-CoV-2 currently exist. A number of drugs that have been approved for other diseases are being tested for the treatment of COVID-19 patients, but there is an absence of data from appropriately designed clinical trials showing that these drugs, either alone or in combination, will prove effective. There is also a global urgency to develop a vaccine against COVID-19, but development and appropriate testing will take at least a year before such a vaccine will be globally available. This review summarizes the lessons learnt so far from the COVID-19 pandemic, examines the evidence regarding the drugs that are being tested for the treatment of COVID19, and describes the progress made in efforts to develop an effective vaccine.Chris R. TriggleDevendra BansalElmoubasher Abu Baker Abd FaragHong DingAli A. SultanAmerican Society for MicrobiologyarticleCOVID-19drugsvaccinesMicrobiologyQR1-502ENmSphere, Vol 5, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 drugs vaccines Microbiology QR1-502
spellingShingle	COVID-19 drugs vaccines Microbiology QR1-502 Chris R. Triggle Devendra Bansal Elmoubasher Abu Baker Abd Farag Hong Ding Ali A. Sultan COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions
description	ABSTRACT Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and first emerged in December 2019 in Wuhan, Hubei province, China. Since then, the virus has rapidly spread to many countries. While the outbreak in China appears to be in decline, the disease has spread across the world, with a daily increase in the number of confirmed cases and infection-related deaths. Here, we highlight (i) the lessons that have been learnt so far and how they will benefit reducing the impact of COVID-19 disease and (ii) an update on the status of drug treatment and vaccine development to prevent COVID-19 and potential future related pandemics. Although the mortality rate is clearly higher than for influenza, the rate does seem to vary from country to country, possibly reflecting differences in how rapidly local health authorities respond to isolate and effectively care for the affected population. Drugs are urgently needed for both prophylaxis and the treatment of severely ill patients; however, no proven effective therapies for SARS-CoV-2 currently exist. A number of drugs that have been approved for other diseases are being tested for the treatment of COVID-19 patients, but there is an absence of data from appropriately designed clinical trials showing that these drugs, either alone or in combination, will prove effective. There is also a global urgency to develop a vaccine against COVID-19, but development and appropriate testing will take at least a year before such a vaccine will be globally available. This review summarizes the lessons learnt so far from the COVID-19 pandemic, examines the evidence regarding the drugs that are being tested for the treatment of COVID19, and describes the progress made in efforts to develop an effective vaccine.
format	article
author	Chris R. Triggle Devendra Bansal Elmoubasher Abu Baker Abd Farag Hong Ding Ali A. Sultan
author_facet	Chris R. Triggle Devendra Bansal Elmoubasher Abu Baker Abd Farag Hong Ding Ali A. Sultan
author_sort	Chris R. Triggle
title	COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions
title_short	COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions
title_full	COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions
title_fullStr	COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions
title_full_unstemmed	COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions
title_sort	covid-19: learning from lessons to guide treatment and prevention interventions
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/dbcf19db4b11485ebbc71d035b98666c
work_keys_str_mv	AT chrisrtriggle covid19learningfromlessonstoguidetreatmentandpreventioninterventions AT devendrabansal covid19learningfromlessonstoguidetreatmentandpreventioninterventions AT elmoubasherabubakerabdfarag covid19learningfromlessonstoguidetreatmentandpreventioninterventions AT hongding covid19learningfromlessonstoguidetreatmentandpreventioninterventions AT aliasultan covid19learningfromlessonstoguidetreatmentandpreventioninterventions
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COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions

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