Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery

Abstract Anastomotic leakage is a complication of colorectal surgery. C-reactive protein (CRP) is an acute-phase marker that can indicate surgical complications. We determined whether serum CRP levels in patients who had undergone colorectal surgery can be used to exclude the presence of anastomotic...

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Autores principales:	Bruno A. Messias, Ricardo V. Botelho, Sarhan S. Saad, Erica R. Mocchetti, Karine C. Turke, Jaques Waisberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dbcfc68e76bd4505a0bf2d8cbc56d7f3
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spelling	oai:doaj.org-article:dbcfc68e76bd4505a0bf2d8cbc56d7f32021-12-02T14:06:51ZSerum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery10.1038/s41598-020-58780-32045-2322https://doaj.org/article/dbcfc68e76bd4505a0bf2d8cbc56d7f32020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-58780-3https://doaj.org/toc/2045-2322Abstract Anastomotic leakage is a complication of colorectal surgery. C-reactive protein (CRP) is an acute-phase marker that can indicate surgical complications. We determined whether serum CRP levels in patients who had undergone colorectal surgery can be used to exclude the presence of anastomotic leakage and allow safe early discharge. We included 90 patients who underwent colorectal surgery with primary anastomosis. Serum CRP levels were measured retrospectively on postoperative days (PODs) 1 – 7. Patients with anastomotic leakage (n = 11) were compared to those without leakage (n = 79). We statistically analysed data and plotted receiver operating characteristic curves. The incidence of anastomotic leakage was 12.2%. Diagnoses were made on PODs 3 – 24. The overall mortality rate was 3.3% (18.2% in the leakage group, 1.3% in the non-leakage group; P < 0.045). CRP levels were most accurate on POD 4, with a cutoff level of 180 mg/L, showing an area under the curve of 0.821 and a negative predictive value of 97.2%. Lower CRP levels after POD 2 and levels <180 mg/L on POD 4 may indicate the absence of anastomotic leakage and may allow safe discharge of patients who had undergone colorectal surgery with primary anastomosis.Bruno A. MessiasRicardo V. BotelhoSarhan S. SaadErica R. MocchettiKarine C. TurkeJaques WaisbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bruno A. Messias Ricardo V. Botelho Sarhan S. Saad Erica R. Mocchetti Karine C. Turke Jaques Waisberg Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery
description	Abstract Anastomotic leakage is a complication of colorectal surgery. C-reactive protein (CRP) is an acute-phase marker that can indicate surgical complications. We determined whether serum CRP levels in patients who had undergone colorectal surgery can be used to exclude the presence of anastomotic leakage and allow safe early discharge. We included 90 patients who underwent colorectal surgery with primary anastomosis. Serum CRP levels were measured retrospectively on postoperative days (PODs) 1 – 7. Patients with anastomotic leakage (n = 11) were compared to those without leakage (n = 79). We statistically analysed data and plotted receiver operating characteristic curves. The incidence of anastomotic leakage was 12.2%. Diagnoses were made on PODs 3 – 24. The overall mortality rate was 3.3% (18.2% in the leakage group, 1.3% in the non-leakage group; P < 0.045). CRP levels were most accurate on POD 4, with a cutoff level of 180 mg/L, showing an area under the curve of 0.821 and a negative predictive value of 97.2%. Lower CRP levels after POD 2 and levels <180 mg/L on POD 4 may indicate the absence of anastomotic leakage and may allow safe discharge of patients who had undergone colorectal surgery with primary anastomosis.
format	article
author	Bruno A. Messias Ricardo V. Botelho Sarhan S. Saad Erica R. Mocchetti Karine C. Turke Jaques Waisberg
author_facet	Bruno A. Messias Ricardo V. Botelho Sarhan S. Saad Erica R. Mocchetti Karine C. Turke Jaques Waisberg
author_sort	Bruno A. Messias
title	Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery
title_short	Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery
title_full	Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery
title_fullStr	Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery
title_full_unstemmed	Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery
title_sort	serum c-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dbcfc68e76bd4505a0bf2d8cbc56d7f3
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Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery

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