A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

Disruption of the ubiquitin proteasome system (UPS) is often associated with neurodegenerative diseases. Here the authors demonstrate the existence of a general mechanism of proteasomal impairment triggered by a specific protein oligomer structure, irrespective of its protein constituent.

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Detalles Bibliográficos
Autores principales:	Tiffany A. Thibaudeau, Raymond T. Anderson, David M. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dbd047c274eb4a5da7f8fbf90d88ffc5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:dbd047c274eb4a5da7f8fbf90d88ffc52021-12-02T16:56:37ZA common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers10.1038/s41467-018-03509-02041-1723https://doaj.org/article/dbd047c274eb4a5da7f8fbf90d88ffc52018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03509-0https://doaj.org/toc/2041-1723Disruption of the ubiquitin proteasome system (UPS) is often associated with neurodegenerative diseases. Here the authors demonstrate the existence of a general mechanism of proteasomal impairment triggered by a specific protein oligomer structure, irrespective of its protein constituent.Tiffany A. ThibaudeauRaymond T. AndersonDavid M. SmithNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tiffany A. Thibaudeau Raymond T. Anderson David M. Smith A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
description	Disruption of the ubiquitin proteasome system (UPS) is often associated with neurodegenerative diseases. Here the authors demonstrate the existence of a general mechanism of proteasomal impairment triggered by a specific protein oligomer structure, irrespective of its protein constituent.
format	article
author	Tiffany A. Thibaudeau Raymond T. Anderson David M. Smith
author_facet	Tiffany A. Thibaudeau Raymond T. Anderson David M. Smith
author_sort	Tiffany A. Thibaudeau
title	A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
title_short	A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
title_full	A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
title_fullStr	A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
title_full_unstemmed	A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
title_sort	common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dbd047c274eb4a5da7f8fbf90d88ffc5
work_keys_str_mv	AT tiffanyathibaudeau acommonmechanismofproteasomeimpairmentbyneurodegenerativediseaseassociatedoligomers AT raymondtanderson acommonmechanismofproteasomeimpairmentbyneurodegenerativediseaseassociatedoligomers AT davidmsmith acommonmechanismofproteasomeimpairmentbyneurodegenerativediseaseassociatedoligomers AT tiffanyathibaudeau commonmechanismofproteasomeimpairmentbyneurodegenerativediseaseassociatedoligomers AT raymondtanderson commonmechanismofproteasomeimpairmentbyneurodegenerativediseaseassociatedoligomers AT davidmsmith commonmechanismofproteasomeimpairmentbyneurodegenerativediseaseassociatedoligomers
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A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

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