Piezoelectric Signals in Vascularized Bone Regeneration

The demand for bone substitutes is increasing in Western countries. Bone graft substitutes aim to provide reconstructive surgeons with off-the-shelf alternatives to the natural bone taken from humans or animal species. Under the tissue engineering paradigm, biomaterial scaffolds can be designed by i...

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Autores principales:	Delfo D’Alessandro, Claudio Ricci, Mario Milazzo, Giovanna Strangis, Francesca Forli, Gabriele Buda, Mario Petrini, Stefano Berrettini, Mohammed Jasim Uddin, Serena Danti, Paolo Parchi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biomaterials scaffold tissue engineering angiogenesis osteogenesis stem cells Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/dbd252c1db3c43daa192938e9f22e815
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spelling	oai:doaj.org-article:dbd252c1db3c43daa192938e9f22e8152021-11-25T16:54:35ZPiezoelectric Signals in Vascularized Bone Regeneration10.3390/biom111117312218-273Xhttps://doaj.org/article/dbd252c1db3c43daa192938e9f22e8152021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1731https://doaj.org/toc/2218-273XThe demand for bone substitutes is increasing in Western countries. Bone graft substitutes aim to provide reconstructive surgeons with off-the-shelf alternatives to the natural bone taken from humans or animal species. Under the tissue engineering paradigm, biomaterial scaffolds can be designed by incorporating bone stem cells to decrease the disadvantages of traditional tissue grafts. However, the effective clinical application of tissue-engineered bone is limited by insufficient neovascularization. As bone is a highly vascularized tissue, new strategies to promote both osteogenesis and vasculogenesis within the scaffolds need to be considered for a successful regeneration. It has been demonstrated that bone and blood vases are piezoelectric, namely, electric signals are locally produced upon mechanical stimulation of these tissues. The specific effects of electric charge generation on different cells are not fully understood, but a substantial amount of evidence has suggested their functional and physiological roles. This review summarizes the special contribution of piezoelectricity as a stimulatory signal for bone and vascular tissue regeneration, including osteogenesis, angiogenesis, vascular repair, and tissue engineering, by considering different stem cell sources entailed with osteogenic and angiogenic potential, aimed at collecting the key findings that may enable the development of successful vascularized bone replacements useful in orthopedic and otologic surgery.Delfo D’AlessandroClaudio RicciMario MilazzoGiovanna StrangisFrancesca ForliGabriele BudaMario PetriniStefano BerrettiniMohammed Jasim UddinSerena DantiPaolo ParchiMDPI AGarticlebiomaterialsscaffoldtissue engineeringangiogenesisosteogenesisstem cellsMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1731, p 1731 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomaterials scaffold tissue engineering angiogenesis osteogenesis stem cells Microbiology QR1-502
spellingShingle	biomaterials scaffold tissue engineering angiogenesis osteogenesis stem cells Microbiology QR1-502 Delfo D’Alessandro Claudio Ricci Mario Milazzo Giovanna Strangis Francesca Forli Gabriele Buda Mario Petrini Stefano Berrettini Mohammed Jasim Uddin Serena Danti Paolo Parchi Piezoelectric Signals in Vascularized Bone Regeneration
description	The demand for bone substitutes is increasing in Western countries. Bone graft substitutes aim to provide reconstructive surgeons with off-the-shelf alternatives to the natural bone taken from humans or animal species. Under the tissue engineering paradigm, biomaterial scaffolds can be designed by incorporating bone stem cells to decrease the disadvantages of traditional tissue grafts. However, the effective clinical application of tissue-engineered bone is limited by insufficient neovascularization. As bone is a highly vascularized tissue, new strategies to promote both osteogenesis and vasculogenesis within the scaffolds need to be considered for a successful regeneration. It has been demonstrated that bone and blood vases are piezoelectric, namely, electric signals are locally produced upon mechanical stimulation of these tissues. The specific effects of electric charge generation on different cells are not fully understood, but a substantial amount of evidence has suggested their functional and physiological roles. This review summarizes the special contribution of piezoelectricity as a stimulatory signal for bone and vascular tissue regeneration, including osteogenesis, angiogenesis, vascular repair, and tissue engineering, by considering different stem cell sources entailed with osteogenic and angiogenic potential, aimed at collecting the key findings that may enable the development of successful vascularized bone replacements useful in orthopedic and otologic surgery.
format	article
author	Delfo D’Alessandro Claudio Ricci Mario Milazzo Giovanna Strangis Francesca Forli Gabriele Buda Mario Petrini Stefano Berrettini Mohammed Jasim Uddin Serena Danti Paolo Parchi
author_facet	Delfo D’Alessandro Claudio Ricci Mario Milazzo Giovanna Strangis Francesca Forli Gabriele Buda Mario Petrini Stefano Berrettini Mohammed Jasim Uddin Serena Danti Paolo Parchi
author_sort	Delfo D’Alessandro
title	Piezoelectric Signals in Vascularized Bone Regeneration
title_short	Piezoelectric Signals in Vascularized Bone Regeneration
title_full	Piezoelectric Signals in Vascularized Bone Regeneration
title_fullStr	Piezoelectric Signals in Vascularized Bone Regeneration
title_full_unstemmed	Piezoelectric Signals in Vascularized Bone Regeneration
title_sort	piezoelectric signals in vascularized bone regeneration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dbd252c1db3c43daa192938e9f22e815
work_keys_str_mv	AT delfodalessandro piezoelectricsignalsinvascularizedboneregeneration AT claudioricci piezoelectricsignalsinvascularizedboneregeneration AT mariomilazzo piezoelectricsignalsinvascularizedboneregeneration AT giovannastrangis piezoelectricsignalsinvascularizedboneregeneration AT francescaforli piezoelectricsignalsinvascularizedboneregeneration AT gabrielebuda piezoelectricsignalsinvascularizedboneregeneration AT mariopetrini piezoelectricsignalsinvascularizedboneregeneration AT stefanoberrettini piezoelectricsignalsinvascularizedboneregeneration AT mohammedjasimuddin piezoelectricsignalsinvascularizedboneregeneration AT serenadanti piezoelectricsignalsinvascularizedboneregeneration AT paoloparchi piezoelectricsignalsinvascularizedboneregeneration
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Piezoelectric Signals in Vascularized Bone Regeneration

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