CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS

Serum concentrations of cytokines (IL-2, IL-6, IL-8, IL-10, GM-CSF, IFNγ, TNFα) were determined in blood serum of pregnant women with different types of metabolic disorders, i.e., gestational diabetes, obesity, and a combination of those disorders. The study was performed by means of flow fluorimetr...

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Autores principales:	T. S. Prokhorenko, A. P. Zima, T. V. Saprina, V. V. Novitskiy, N. M. Todosenko, L. S. Litvinova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	cytokines pregnancy obesity gestational diabetes mellitus Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/dbd65b28991140b7b7daa3dc4c0e5f1f
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spelling	oai:doaj.org-article:dbd65b28991140b7b7daa3dc4c0e5f1f2021-11-18T08:03:46ZCYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS1563-06252313-741X10.15789/1563-0625-2017-3-301-306https://doaj.org/article/dbd65b28991140b7b7daa3dc4c0e5f1f2017-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1264https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSerum concentrations of cytokines (IL-2, IL-6, IL-8, IL-10, GM-CSF, IFNγ, TNFα) were determined in blood serum of pregnant women with different types of metabolic disorders, i.e., gestational diabetes, obesity, and a combination of those disorders. The study was performed by means of flow fluorimetry, using a multiplex test system. Changes of cytokine profiles in pregnant women with overweight or obesity, and pregnant women with gestational diabetes showed some similarities. In pregnant women with overweight or obesity we have found an increase in blood concentrations of IL-2, IL-6, IL-10, IFNγ, and TNFa. Meanwhile, an increase in blood levels of IL-2, IL-6, IL-10 and TNFα was revealed in pregnant women with gestational diabetes. The changes in cytokine profile were most pronounced in cases of pregnancy complicated with gestational diabetes and obesity. In these women, increased IL-6, TNFα, GM-CSF and IFNg concentrations were revealed in blood, along with low contents of IL-2 and IL-10. Potential causes and consequences of suggested subclinical inflammation in pregnant women are discussed. We conclude that pregnant women with metabolic disorders may develop a subclinical inflammation at the early stages of obesity, or metabolic disturbances.T. S. ProkhorenkoA. P. ZimaT. V. SaprinaV. V. NovitskiyN. M. TodosenkoL. S. LitvinovaSPb RAACIarticlecytokinespregnancyobesitygestational diabetes mellitusImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 3, Pp 301-306 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines pregnancy obesity gestational diabetes mellitus Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines pregnancy obesity gestational diabetes mellitus Immunologic diseases. Allergy RC581-607 T. S. Prokhorenko A. P. Zima T. V. Saprina V. V. Novitskiy N. M. Todosenko L. S. Litvinova CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS
description	Serum concentrations of cytokines (IL-2, IL-6, IL-8, IL-10, GM-CSF, IFNγ, TNFα) were determined in blood serum of pregnant women with different types of metabolic disorders, i.e., gestational diabetes, obesity, and a combination of those disorders. The study was performed by means of flow fluorimetry, using a multiplex test system. Changes of cytokine profiles in pregnant women with overweight or obesity, and pregnant women with gestational diabetes showed some similarities. In pregnant women with overweight or obesity we have found an increase in blood concentrations of IL-2, IL-6, IL-10, IFNγ, and TNFa. Meanwhile, an increase in blood levels of IL-2, IL-6, IL-10 and TNFα was revealed in pregnant women with gestational diabetes. The changes in cytokine profile were most pronounced in cases of pregnancy complicated with gestational diabetes and obesity. In these women, increased IL-6, TNFα, GM-CSF and IFNg concentrations were revealed in blood, along with low contents of IL-2 and IL-10. Potential causes and consequences of suggested subclinical inflammation in pregnant women are discussed. We conclude that pregnant women with metabolic disorders may develop a subclinical inflammation at the early stages of obesity, or metabolic disturbances.
format	article
author	T. S. Prokhorenko A. P. Zima T. V. Saprina V. V. Novitskiy N. M. Todosenko L. S. Litvinova
author_facet	T. S. Prokhorenko A. P. Zima T. V. Saprina V. V. Novitskiy N. M. Todosenko L. S. Litvinova
author_sort	T. S. Prokhorenko
title	CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS
title_short	CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS
title_full	CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS
title_fullStr	CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS
title_full_unstemmed	CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS
title_sort	cytokine profile in pregnant women with metabolic disorders
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/dbd65b28991140b7b7daa3dc4c0e5f1f
work_keys_str_mv	AT tsprokhorenko cytokineprofileinpregnantwomenwithmetabolicdisorders AT apzima cytokineprofileinpregnantwomenwithmetabolicdisorders AT tvsaprina cytokineprofileinpregnantwomenwithmetabolicdisorders AT vvnovitskiy cytokineprofileinpregnantwomenwithmetabolicdisorders AT nmtodosenko cytokineprofileinpregnantwomenwithmetabolicdisorders AT lslitvinova cytokineprofileinpregnantwomenwithmetabolicdisorders
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CYTOKINE PROFILE IN PREGNANT WOMEN WITH METABOLIC DISORDERS

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