SERS discrimination of single DNA bases in single oligonucleotides by electro-plasmonic trapping

Sensing DNA bases by surface-enhanced Raman spectroscopy (SERS) in plasmonic nanopores has suffered from rapid flow through of molecules. Here, the authors attach DNA molecules to gold nanoparticles which, due to electro-plasmonic trapping, allow for controlled residence times and discrimination of...

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Autores principales: Jian-An Huang, Mansoureh Z. Mousavi, Yingqi Zhao, Aliaksandr Hubarevich, Fatima Omeis, Giorgia Giovannini, Moritz Schütte, Denis Garoli, Francesco De Angelis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/dbd9b53ffbea4edea77b7c3a88a2c37e
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Sumario:Sensing DNA bases by surface-enhanced Raman spectroscopy (SERS) in plasmonic nanopores has suffered from rapid flow through of molecules. Here, the authors attach DNA molecules to gold nanoparticles which, due to electro-plasmonic trapping, allow for controlled residence times and discrimination of single nucleotides.