3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

Long-term in vitro models for hepatitis B virus (HBV) infection are important to understand this infection, but are lacking. Here the authors develop a microfluidic primary human hepatocyte organoid culture system that can be maintained over 40 days and recapitulates all of the steps of the HBV life...

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Autores principales:	A. M. Ortega-Prieto, J. K. Skelton, S. N. Wai, E. Large, M. Lussignol, G. Vizcay-Barrena, D. Hughes, R. A. Fleck, M. Thursz, M. T. Catanese, M. Dorner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dbd9cac46ae647deba35c1db7c363564
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spelling	oai:doaj.org-article:dbd9cac46ae647deba35c1db7c3635642021-12-02T17:32:15Z3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection10.1038/s41467-018-02969-82041-1723https://doaj.org/article/dbd9cac46ae647deba35c1db7c3635642018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02969-8https://doaj.org/toc/2041-1723Long-term in vitro models for hepatitis B virus (HBV) infection are important to understand this infection, but are lacking. Here the authors develop a microfluidic primary human hepatocyte organoid culture system that can be maintained over 40 days and recapitulates all of the steps of the HBV life cycle.A. M. Ortega-PrietoJ. K. SkeltonS. N. WaiE. LargeM. LussignolG. Vizcay-BarrenaD. HughesR. A. FleckM. ThurszM. T. CataneseM. DornerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. M. Ortega-Prieto J. K. Skelton S. N. Wai E. Large M. Lussignol G. Vizcay-Barrena D. Hughes R. A. Fleck M. Thursz M. T. Catanese M. Dorner 3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
description	Long-term in vitro models for hepatitis B virus (HBV) infection are important to understand this infection, but are lacking. Here the authors develop a microfluidic primary human hepatocyte organoid culture system that can be maintained over 40 days and recapitulates all of the steps of the HBV life cycle.
format	article
author	A. M. Ortega-Prieto J. K. Skelton S. N. Wai E. Large M. Lussignol G. Vizcay-Barrena D. Hughes R. A. Fleck M. Thursz M. T. Catanese M. Dorner
author_facet	A. M. Ortega-Prieto J. K. Skelton S. N. Wai E. Large M. Lussignol G. Vizcay-Barrena D. Hughes R. A. Fleck M. Thursz M. T. Catanese M. Dorner
author_sort	A. M. Ortega-Prieto
title	3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
title_short	3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
title_full	3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
title_fullStr	3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
title_full_unstemmed	3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
title_sort	3d microfluidic liver cultures as a physiological preclinical tool for hepatitis b virus infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dbd9cac46ae647deba35c1db7c363564
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3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

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