3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

Long-term in vitro models for hepatitis B virus (HBV) infection are important to understand this infection, but are lacking. Here the authors develop a microfluidic primary human hepatocyte organoid culture system that can be maintained over 40 days and recapitulates all of the steps of the HBV life...

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Bibliographic Details
Main Authors: A. M. Ortega-Prieto, J. K. Skelton, S. N. Wai, E. Large, M. Lussignol, G. Vizcay-Barrena, D. Hughes, R. A. Fleck, M. Thursz, M. T. Catanese, M. Dorner
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/dbd9cac46ae647deba35c1db7c363564
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