Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.

Type 2 diabetes mellitus (T2DM) adversely affects the normal functioning, intrinsic material properties, and structural integrity of many tissues, including bone. It is well known that the clinical utility of areal bone mineral density (aBMD) is limited to assess bone strength in individuals with T2...

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Autores principales:	Praveer Sihota, Rimesh Pal, Ram Naresh Yadav, Deepak Neradi, Shailesh Karn, Vijay G Goni, Siddhartha Sharma, Vishwajeet Mehandia, Sanjay Kumar Bhadada, Navin Kumar, Sudhaker D Rao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dbdd02269b8a42acb7374d10d34c3245
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spelling	oai:doaj.org-article:dbdd02269b8a42acb7374d10d34c32452021-12-02T20:13:55ZCan fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.1932-620310.1371/journal.pone.0257955https://doaj.org/article/dbdd02269b8a42acb7374d10d34c32452021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257955https://doaj.org/toc/1932-6203Type 2 diabetes mellitus (T2DM) adversely affects the normal functioning, intrinsic material properties, and structural integrity of many tissues, including bone. It is well known that the clinical utility of areal bone mineral density (aBMD) is limited to assess bone strength in individuals with T2DM. Therefore, there is a need to explore new diagnostic techniques that can better assist and improve the accuracy of assessment of bone tissue quality. The present study investigated the link between bone and fingernail material/compositional properties in type 2 diabetes mellitus (T2DM). For that, femoral head and fingernail samples were obtained from twenty-five adult female patients (with/without T2DM) with fragility femoral neck fractures undergoing hemi/total hip arthroplasty. Cylindrical cores of trabecular bone were subjected to micro-CT, and lower bone volume fraction was observed in the diabetic group than the non-diabetic group due to fewer and thinner trabeculae in individuals with T2DM. The material and compositional properties of bone/fingernail were estimated using nanoindentation and Fourier Transform Infrared Spectroscopy, respectively. Both bone/fingernails in T2DM had lower reduced modulus (Er), hardness (H), lower Amide I and Amide II area ratio (protein content), higher sugar-to-matrix ratio, and relatively high carboxymethyl-lysine (CML) content compared with non-diabetic patients. Sugar-to-matrix ratio and relative CML content were strongly and positively correlated with HbA1c for both bone/fingernail. There was a positive correlation between bone and fingernail glycation content. Our findings provide evidence that the degradation pattern of bone and fingernail properties go hand-in-hand in individuals with T2DM. Hence, the fingernail compositional/material properties might serve as a non-invasive surrogate marker of bone quality in T2DM; however, further large-scale studies need to be undertaken.Praveer SihotaRimesh PalRam Naresh YadavDeepak NeradiShailesh KarnVijay G GoniSiddhartha SharmaVishwajeet MehandiaSanjay Kumar BhadadaNavin KumarSudhaker D RaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257955 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Praveer Sihota Rimesh Pal Ram Naresh Yadav Deepak Neradi Shailesh Karn Vijay G Goni Siddhartha Sharma Vishwajeet Mehandia Sanjay Kumar Bhadada Navin Kumar Sudhaker D Rao Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.
description	Type 2 diabetes mellitus (T2DM) adversely affects the normal functioning, intrinsic material properties, and structural integrity of many tissues, including bone. It is well known that the clinical utility of areal bone mineral density (aBMD) is limited to assess bone strength in individuals with T2DM. Therefore, there is a need to explore new diagnostic techniques that can better assist and improve the accuracy of assessment of bone tissue quality. The present study investigated the link between bone and fingernail material/compositional properties in type 2 diabetes mellitus (T2DM). For that, femoral head and fingernail samples were obtained from twenty-five adult female patients (with/without T2DM) with fragility femoral neck fractures undergoing hemi/total hip arthroplasty. Cylindrical cores of trabecular bone were subjected to micro-CT, and lower bone volume fraction was observed in the diabetic group than the non-diabetic group due to fewer and thinner trabeculae in individuals with T2DM. The material and compositional properties of bone/fingernail were estimated using nanoindentation and Fourier Transform Infrared Spectroscopy, respectively. Both bone/fingernails in T2DM had lower reduced modulus (Er), hardness (H), lower Amide I and Amide II area ratio (protein content), higher sugar-to-matrix ratio, and relatively high carboxymethyl-lysine (CML) content compared with non-diabetic patients. Sugar-to-matrix ratio and relative CML content were strongly and positively correlated with HbA1c for both bone/fingernail. There was a positive correlation between bone and fingernail glycation content. Our findings provide evidence that the degradation pattern of bone and fingernail properties go hand-in-hand in individuals with T2DM. Hence, the fingernail compositional/material properties might serve as a non-invasive surrogate marker of bone quality in T2DM; however, further large-scale studies need to be undertaken.
format	article
author	Praveer Sihota Rimesh Pal Ram Naresh Yadav Deepak Neradi Shailesh Karn Vijay G Goni Siddhartha Sharma Vishwajeet Mehandia Sanjay Kumar Bhadada Navin Kumar Sudhaker D Rao
author_facet	Praveer Sihota Rimesh Pal Ram Naresh Yadav Deepak Neradi Shailesh Karn Vijay G Goni Siddhartha Sharma Vishwajeet Mehandia Sanjay Kumar Bhadada Navin Kumar Sudhaker D Rao
author_sort	Praveer Sihota
title	Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.
title_short	Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.
title_full	Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.
title_fullStr	Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.
title_full_unstemmed	Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.
title_sort	can fingernail quality predict bone damage in type 2 diabetes mellitus? a pilot study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dbdd02269b8a42acb7374d10d34c3245
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Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.

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