Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development.
The pro-carcinogenic effects of prostaglandin E2 (PGE2) in colonic mucosa are not only regulated by the rates between Cyclooxygenase-2 (COX-2) biosynthesis and 15-Hydroxyprostaglandin Dehydrogenase (15-PGDH)-dependent degradation but also the steady-state levels of PGE2 in extracellular microenviron...
Guardado en:
Autores principales: | Carina Pereira, Sara Queirós, Ana Galaghar, Hugo Sousa, Pedro Pimentel-Nunes, Catarina Brandão, Luís Moreira-Dias, Rui Medeiros, Mário Dinis-Ribeiro |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
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Materias: | |
Acceso en línea: | https://doaj.org/article/dbe09f6887c3437aaa845c696b4f9a45 |
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