Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inhibition of this mechanism significantly decreases...

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Autores principales:	Hasini Jayatilaka, Pranay Tyle, Jonathan J. Chen, Minsuk Kwak, Julia Ju, Hyun Ji Kim, Jerry S. H. Lee, Pei-Hsun Wu, Daniele M. Gilkes, Rong Fan, Denis Wirtz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dbe0f12d5d9d4050b25725c41849802f
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spelling	oai:doaj.org-article:dbe0f12d5d9d4050b25725c41849802f2021-12-02T14:42:41ZSynergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration10.1038/ncomms155842041-1723https://doaj.org/article/dbe0f12d5d9d4050b25725c41849802f2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15584https://doaj.org/toc/2041-1723Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inhibition of this mechanism significantly decreases metastasis in mouse xenograft models.Hasini JayatilakaPranay TyleJonathan J. ChenMinsuk KwakJulia JuHyun Ji KimJerry S. H. LeePei-Hsun WuDaniele M. GilkesRong FanDenis WirtzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hasini Jayatilaka Pranay Tyle Jonathan J. Chen Minsuk Kwak Julia Ju Hyun Ji Kim Jerry S. H. Lee Pei-Hsun Wu Daniele M. Gilkes Rong Fan Denis Wirtz Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
description	Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inhibition of this mechanism significantly decreases metastasis in mouse xenograft models.
format	article
author	Hasini Jayatilaka Pranay Tyle Jonathan J. Chen Minsuk Kwak Julia Ju Hyun Ji Kim Jerry S. H. Lee Pei-Hsun Wu Daniele M. Gilkes Rong Fan Denis Wirtz
author_facet	Hasini Jayatilaka Pranay Tyle Jonathan J. Chen Minsuk Kwak Julia Ju Hyun Ji Kim Jerry S. H. Lee Pei-Hsun Wu Daniele M. Gilkes Rong Fan Denis Wirtz
author_sort	Hasini Jayatilaka
title	Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
title_short	Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
title_full	Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
title_fullStr	Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
title_full_unstemmed	Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
title_sort	synergistic il-6 and il-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dbe0f12d5d9d4050b25725c41849802f
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Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

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