A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

HIV-1 viral gene expression stochastically switches between active and inactive states. Here, using improved single molecule RNA microscopy, the authors show that HIV-1 RNA stochastic transcription is achieved by groups of closely spaced polymerases, and is regulated by Mediator and TBP at different...

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Autores principales:	Katjana Tantale, Florian Mueller, Alja Kozulic-Pirher, Annick Lesne, Jean-Marc Victor, Marie-Cécile Robert, Serena Capozi, Racha Chouaib, Volker Bäcker, Julio Mateos-Langerak, Xavier Darzacq, Christophe Zimmer, Eugenia Basyuk, Edouard Bertrand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dbe244ad77fd496b96bf165adab3bfd8
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spelling	oai:doaj.org-article:dbe244ad77fd496b96bf165adab3bfd82021-12-02T14:38:56ZA single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting10.1038/ncomms122482041-1723https://doaj.org/article/dbe244ad77fd496b96bf165adab3bfd82016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12248https://doaj.org/toc/2041-1723HIV-1 viral gene expression stochastically switches between active and inactive states. Here, using improved single molecule RNA microscopy, the authors show that HIV-1 RNA stochastic transcription is achieved by groups of closely spaced polymerases, and is regulated by Mediator and TBP at different time scales.Katjana TantaleFlorian MuellerAlja Kozulic-PirherAnnick LesneJean-Marc VictorMarie-Cécile RobertSerena CapoziRacha ChouaibVolker BäckerJulio Mateos-LangerakXavier DarzacqChristophe ZimmerEugenia BasyukEdouard BertrandNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katjana Tantale Florian Mueller Alja Kozulic-Pirher Annick Lesne Jean-Marc Victor Marie-Cécile Robert Serena Capozi Racha Chouaib Volker Bäcker Julio Mateos-Langerak Xavier Darzacq Christophe Zimmer Eugenia Basyuk Edouard Bertrand A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
description	HIV-1 viral gene expression stochastically switches between active and inactive states. Here, using improved single molecule RNA microscopy, the authors show that HIV-1 RNA stochastic transcription is achieved by groups of closely spaced polymerases, and is regulated by Mediator and TBP at different time scales.
format	article
author	Katjana Tantale Florian Mueller Alja Kozulic-Pirher Annick Lesne Jean-Marc Victor Marie-Cécile Robert Serena Capozi Racha Chouaib Volker Bäcker Julio Mateos-Langerak Xavier Darzacq Christophe Zimmer Eugenia Basyuk Edouard Bertrand
author_facet	Katjana Tantale Florian Mueller Alja Kozulic-Pirher Annick Lesne Jean-Marc Victor Marie-Cécile Robert Serena Capozi Racha Chouaib Volker Bäcker Julio Mateos-Langerak Xavier Darzacq Christophe Zimmer Eugenia Basyuk Edouard Bertrand
author_sort	Katjana Tantale
title	A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
title_short	A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
title_full	A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
title_fullStr	A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
title_full_unstemmed	A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
title_sort	single-molecule view of transcription reveals convoys of rna polymerases and multi-scale bursting
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dbe244ad77fd496b96bf165adab3bfd8
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A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

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