A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

HIV-1 viral gene expression stochastically switches between active and inactive states. Here, using improved single molecule RNA microscopy, the authors show that HIV-1 RNA stochastic transcription is achieved by groups of closely spaced polymerases, and is regulated by Mediator and TBP at different...

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Autores principales: Katjana Tantale, Florian Mueller, Alja Kozulic-Pirher, Annick Lesne, Jean-Marc Victor, Marie-Cécile Robert, Serena Capozi, Racha Chouaib, Volker Bäcker, Julio Mateos-Langerak, Xavier Darzacq, Christophe Zimmer, Eugenia Basyuk, Edouard Bertrand
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/dbe244ad77fd496b96bf165adab3bfd8
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