Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization

Abstract Background Inoperable hepatocellular carcinoma (HCC) is treated by conventional transarterial chemoembolization (cTACE) using cone-beam computed tomography (CBCT) or digital subtraction angiography (DSA). We compared patient survival outcomes between CBCT-cTACE with automated tumor-feeder d...

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Autores principales:	Kittipitch Bannangkoon, Keerati Hongsakul, Teeravut Tubtawee
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cone-beam computed tomography Software tools Survival rate Hepatocellular carcinoma Therapeutic chemoembolization Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/dbe7f77d597542e78b6613e9e24d064a
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spelling	oai:doaj.org-article:dbe7f77d597542e78b6613e9e24d064a2021-11-14T12:16:53ZImpact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization10.1186/s12876-021-02004-z1471-230Xhttps://doaj.org/article/dbe7f77d597542e78b6613e9e24d064a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02004-zhttps://doaj.org/toc/1471-230XAbstract Background Inoperable hepatocellular carcinoma (HCC) is treated by conventional transarterial chemoembolization (cTACE) using cone-beam computed tomography (CBCT) or digital subtraction angiography (DSA). We compared patient survival outcomes between CBCT-cTACE with automated tumor-feeder detection (AFD) software and DSA-cTACE alone in inoperable HCC patients. Methods We reviewed the data of 337 HCC patients treated by CBCT-cTACE or DSA-cTACE between January 2015 and December 2019. Treatment response, progression-free survival (PFS), overall survival (OS), and complications between the CBCT-cTACE and DSA-cTACE groups were compared. Univariate and multivariate logistic regression analyses examined the potential prognostic factors affecting survival after chemoembolization. Results Tumor response rates in complete response, partial response, and stable disease at 1 month were 67%, 28%, and 4% in the CBCT-cTACE group and 22%, 48%, and 9% in the DSA-cTACE group, respectively. OS rates of patients in the CBCT-cTACE versus DSA-cTACE groups were 87% versus 54%, 44% versus 15%, and 34% versus 7% at 1, 3, and 5 years, respectively. The CBCT-cTACE group had significantly improved PFS (p < 0.001) and OS (p < 0.001). Multivariate analysis showed that CBCT with AFD software was an independent factor associated with longer OS (hazard ratio, 0.38; p < 0.001). Conclusions Compared with conventional DSA, combining selective cTACE with CBCT and AFD software leads to better tumor response and prolongs OS in patients with inoperable HCC.Kittipitch BannangkoonKeerati HongsakulTeeravut TubtaweeBMCarticleCone-beam computed tomographySoftware toolsSurvival rateHepatocellular carcinomaTherapeutic chemoembolizationDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cone-beam computed tomography Software tools Survival rate Hepatocellular carcinoma Therapeutic chemoembolization Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Cone-beam computed tomography Software tools Survival rate Hepatocellular carcinoma Therapeutic chemoembolization Diseases of the digestive system. Gastroenterology RC799-869 Kittipitch Bannangkoon Keerati Hongsakul Teeravut Tubtawee Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization
description	Abstract Background Inoperable hepatocellular carcinoma (HCC) is treated by conventional transarterial chemoembolization (cTACE) using cone-beam computed tomography (CBCT) or digital subtraction angiography (DSA). We compared patient survival outcomes between CBCT-cTACE with automated tumor-feeder detection (AFD) software and DSA-cTACE alone in inoperable HCC patients. Methods We reviewed the data of 337 HCC patients treated by CBCT-cTACE or DSA-cTACE between January 2015 and December 2019. Treatment response, progression-free survival (PFS), overall survival (OS), and complications between the CBCT-cTACE and DSA-cTACE groups were compared. Univariate and multivariate logistic regression analyses examined the potential prognostic factors affecting survival after chemoembolization. Results Tumor response rates in complete response, partial response, and stable disease at 1 month were 67%, 28%, and 4% in the CBCT-cTACE group and 22%, 48%, and 9% in the DSA-cTACE group, respectively. OS rates of patients in the CBCT-cTACE versus DSA-cTACE groups were 87% versus 54%, 44% versus 15%, and 34% versus 7% at 1, 3, and 5 years, respectively. The CBCT-cTACE group had significantly improved PFS (p < 0.001) and OS (p < 0.001). Multivariate analysis showed that CBCT with AFD software was an independent factor associated with longer OS (hazard ratio, 0.38; p < 0.001). Conclusions Compared with conventional DSA, combining selective cTACE with CBCT and AFD software leads to better tumor response and prolongs OS in patients with inoperable HCC.
format	article
author	Kittipitch Bannangkoon Keerati Hongsakul Teeravut Tubtawee
author_facet	Kittipitch Bannangkoon Keerati Hongsakul Teeravut Tubtawee
author_sort	Kittipitch Bannangkoon
title	Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization
title_short	Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization
title_full	Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization
title_fullStr	Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization
title_full_unstemmed	Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization
title_sort	impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization
publisher	BMC
publishDate	2021
url	https://doaj.org/article/dbe7f77d597542e78b6613e9e24d064a
work_keys_str_mv	AT kittipitchbannangkoon impactofconebeamcomputedtomographywithautomatedfeederdetectionsoftwareonthesurvivaloutcomeofpatientswithhepatocellularcarcinomaduringtreatmentwithconventionaltransarterialchemoembolization AT keeratihongsakul impactofconebeamcomputedtomographywithautomatedfeederdetectionsoftwareonthesurvivaloutcomeofpatientswithhepatocellularcarcinomaduringtreatmentwithconventionaltransarterialchemoembolization AT teeravuttubtawee impactofconebeamcomputedtomographywithautomatedfeederdetectionsoftwareonthesurvivaloutcomeofpatientswithhepatocellularcarcinomaduringtreatmentwithconventionaltransarterialchemoembolization
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Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization

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