Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

Deregulation of transcription factors is frequently observed in cancer. Here, the authors develop a blood-based approach to map transcription factor binding, revealing both patient-specific and tumour-specific aberrations

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Autores principales:	Peter Ulz, Samantha Perakis, Qing Zhou, Tina Moser, Jelena Belic, Isaac Lazzeri, Albert Wölfler, Armin Zebisch, Armin Gerger, Gunda Pristauz, Edgar Petru, Brandon White, Charles E. S. Roberts, John St. John, Michael G. Schimek, Jochen B. Geigl, Thomas Bauernhofer, Heinz Sill, Christoph Bock, Ellen Heitzer, Michael R. Speicher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dbef1e4364b449e490e94bf709b557cd
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spelling	oai:doaj.org-article:dbef1e4364b449e490e94bf709b557cd2021-12-02T14:39:01ZInference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection10.1038/s41467-019-12714-42041-1723https://doaj.org/article/dbef1e4364b449e490e94bf709b557cd2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12714-4https://doaj.org/toc/2041-1723Deregulation of transcription factors is frequently observed in cancer. Here, the authors develop a blood-based approach to map transcription factor binding, revealing both patient-specific and tumour-specific aberrationsPeter UlzSamantha PerakisQing ZhouTina MoserJelena BelicIsaac LazzeriAlbert WölflerArmin ZebischArmin GergerGunda PristauzEdgar PetruBrandon WhiteCharles E. S. RobertsJohn St. JohnMichael G. SchimekJochen B. GeiglThomas BauernhoferHeinz SillChristoph BockEllen HeitzerMichael R. SpeicherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter Ulz Samantha Perakis Qing Zhou Tina Moser Jelena Belic Isaac Lazzeri Albert Wölfler Armin Zebisch Armin Gerger Gunda Pristauz Edgar Petru Brandon White Charles E. S. Roberts John St. John Michael G. Schimek Jochen B. Geigl Thomas Bauernhofer Heinz Sill Christoph Bock Ellen Heitzer Michael R. Speicher Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
description	Deregulation of transcription factors is frequently observed in cancer. Here, the authors develop a blood-based approach to map transcription factor binding, revealing both patient-specific and tumour-specific aberrations
format	article
author	Peter Ulz Samantha Perakis Qing Zhou Tina Moser Jelena Belic Isaac Lazzeri Albert Wölfler Armin Zebisch Armin Gerger Gunda Pristauz Edgar Petru Brandon White Charles E. S. Roberts John St. John Michael G. Schimek Jochen B. Geigl Thomas Bauernhofer Heinz Sill Christoph Bock Ellen Heitzer Michael R. Speicher
author_facet	Peter Ulz Samantha Perakis Qing Zhou Tina Moser Jelena Belic Isaac Lazzeri Albert Wölfler Armin Zebisch Armin Gerger Gunda Pristauz Edgar Petru Brandon White Charles E. S. Roberts John St. John Michael G. Schimek Jochen B. Geigl Thomas Bauernhofer Heinz Sill Christoph Bock Ellen Heitzer Michael R. Speicher
author_sort	Peter Ulz
title	Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
title_short	Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
title_full	Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
title_fullStr	Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
title_full_unstemmed	Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
title_sort	inference of transcription factor binding from cell-free dna enables tumor subtype prediction and early detection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dbef1e4364b449e490e94bf709b557cd
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Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

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