A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

SFPQ is a splicing factor and its mutations are associated to amyotrophic lateral sclerosis (ALS) patients. Here, the authors show that SFPQ represses the use of pathogenic cryptic last exons in zebrafish, mouse and human cells.

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Auteurs principaux:	Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev, Corinne Houart
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/dbf009023d6d49ffada9dbd438aaf6be
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spelling	oai:doaj.org-article:dbf009023d6d49ffada9dbd438aaf6be2021-12-02T11:44:50ZA conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons10.1038/s41467-021-22098-z2041-1723https://doaj.org/article/dbf009023d6d49ffada9dbd438aaf6be2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22098-zhttps://doaj.org/toc/2041-1723SFPQ is a splicing factor and its mutations are associated to amyotrophic lateral sclerosis (ALS) patients. Here, the authors show that SFPQ represses the use of pathogenic cryptic last exons in zebrafish, mouse and human cells.Patricia M. GordonFursham HamidEugene V. MakeyevCorinne HouartNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia M. Gordon Fursham Hamid Eugene V. Makeyev Corinne Houart A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
description	SFPQ is a splicing factor and its mutations are associated to amyotrophic lateral sclerosis (ALS) patients. Here, the authors show that SFPQ represses the use of pathogenic cryptic last exons in zebrafish, mouse and human cells.
format	article
author	Patricia M. Gordon Fursham Hamid Eugene V. Makeyev Corinne Houart
author_facet	Patricia M. Gordon Fursham Hamid Eugene V. Makeyev Corinne Houart
author_sort	Patricia M. Gordon
title	A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
title_short	A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
title_full	A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
title_fullStr	A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
title_full_unstemmed	A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
title_sort	conserved role for the als-linked splicing factor sfpq in repression of pathogenic cryptic last exons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dbf009023d6d49ffada9dbd438aaf6be
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A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

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