A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

SFPQ is a splicing factor and its mutations are associated to amyotrophic lateral sclerosis (ALS) patients. Here, the authors show that SFPQ represses the use of pathogenic cryptic last exons in zebrafish, mouse and human cells.

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Detalles Bibliográficos
Autores principales: Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev, Corinne Houart
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/dbf009023d6d49ffada9dbd438aaf6be
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